The province of Isernia (Italian: provincia di Isernia) is a province in the Molise region of Italy. The provincial capital is the city Isernia and the president of the province is Alfredo Ricci. The province of Isernia has an area of 1,535.24 square kilometres (592.76 sq mi) and a population of 79,236 inhabitants as of 2024, making it Italy's least populous province. It contains 52 comuni (sg.: comune) in the province, listed at comuni of the province of Isernia.