Qamishli (Kurdish: Qamişlo, Arabic: القامشلي, Syriac: ܩܡܫܠܝ) is a city in northeastern Syria on the Syria–Turkey border, adjoining the city of Nusaybin in Turkey. The Jaghjagh River flows through the city. With a 2004 census population of 184,231, it is the ninth most-populous city in Syria and the second-largest in Al-Hasakah Governorate after Al-Hasakah. Qamishli has traditionally been a Christian Assyrian majority city, but is now predominantly populated by Kurds with large numbers of Arabs and Assyrians and a smaller number of Armenians. It is 680 kilometres (420 mi) northeast of Damascus.
The city is the administrative capital of the Qamishli District in Al-Hasakah Governorate, and the administrative center of Qamishli Subdistrict, consisting of 92 localities with a combined population of 232,095 in 2004. Qamishli was the de facto capital of the DAANES, until it was moved to Ayn Issa.