Mithridatic Wars in the context of "Mosaics of Delos"

Pontus (Ancient Greek: Πόντος Pontos) was a Hellenistic kingdom centered in the historical region of Pontus in modern-day Turkey, and ruled by the Mithridatic dynasty of Persian origin, which may have been directly related to Darius the Great of the Achaemenid dynasty. The kingdom was proclaimed by Mithridates I in 281 BC and lasted until its conquest by the Roman Republic in 63 BC. The Kingdom of Pontus reached its greatest extent under Mithridates VI the Great, who conquered Colchis, Cappadocia, Bithynia, the Greek colonies of the Tauric Chersonesos, and for a brief time the Roman province of Asia. After a long struggle with Rome in the Mithridatic Wars, Pontus was defeated.

The kingdom had three cultural strands, which often fused together: Greek (mostly on the coast), Persian, and Anatolian, with Greek becoming the official language in the 3rd century BC.

Mithridates or Mithradates VI Eupator (Ancient Greek: Μιθριδάτης; 135–63 BC) was the ruler of the Kingdom of Pontus in northern Anatolia from 120 to 63 BC, and one of the Roman Republic's most formidable and determined opponents. He was an intelligent, effective, ambitious, and ruthless ruler who sought to dominate Asia Minor and the Black Sea region, waging several hard-fought but ultimately unsuccessful wars (the Mithridatic Wars) to break Roman dominion over Asia and the Hellenic world. He has been called the greatest ruler of the Kingdom of Pontus. He cultivated an immunity to poisons by regularly ingesting sub-lethal doses; this practice, now called mithridatism, is named after him. After his death, he became known as Mithridates the Great.

The Mithridatic dynasty, also known as the Pontic dynasty, was a hereditary dynasty of Persian origin, founded by Mithridates I Ktistes (Mithridates III of Cius) in 281 BC. The origins of the dynasty were located in the highest circles of the ruling Persian nobility in Cius. Mithridates III of Cius fled to Paphlagonia after the murder of his father and his predecessor Mithridates II of Cius, eventually proclaiming the Kingdom of Pontus, and adopting the epithet of "Ktistes" (literally, Builder). The dynasty reached its greatest extent under the rule of Mithridates VI, who is considered the greatest ruler of the Kingdom of Pontus.

They were prominent enemies of the Roman Republic during the Mithridatic Wars during the reign of Mithridates VI until the late 60s BC. In 48 BC, the Roman client king of the Crimea, Pharnaces II, attempted to press his claim on Pontus, but was decisively defeated by Julius Caesar at the Battle of Zela.

The Third Mithridatic War (73–63 BC), the last and longest of the three Mithridatic Wars, was fought between Mithridates VI of Pontus and the Roman Republic. Both sides were joined by a great number of allies, dragging the entire east of the Mediterranean and large parts of Asia (Asia Minor, Greater Armenia, northern Mesopotamia and the Levant) into the war. The conflict ended in defeat for Mithridates; it ended the Pontic Kingdom and the Seleucid Empire (by then a rump state), and also resulted in the Kingdom of Armenia becoming an allied client state of Rome.