Mithridates VI Eupator in the context of "Tigranes the Great"

The First Mithridatic War (89–85 BC) was a large conflict in Anatolia and ancient Greece that opposed the Roman Republic and the Pontic kingdom ruled by Mithridates VI Eupator. Although the Roman general Sulla was largely victorious on the battlefield, factional struggle in Rome forced him to end the war on a precarious stalemate.

The war began after more than a decade of geopolitical manoeuvring by Mithridates, who managed to considerably extend his realm despite constant Roman attempts to restrain him. In 90 BC, a Roman delegation headed by Manius Aquillius provoked Mithridates into war, as Aquillius hoped to receive its command. The following year, Mithridates rapidly captured the Roman province of Asia, exploiting local resentment of Roman tax collectors to massacre the Roman settlers. Taken by surprise while it was fighting a large revolt of its allies in Italy, Rome was initially unable to respond. This allowed Mithridates to encourage more defections from Greek cities, most notably Athens, where he installed the tyrant Aristion.

The March on Rome of 88 BC was a coup d'état by the consul of the Roman Republic Lucius Cornelius Sulla, who seized power against his enemies Marius and Sulpicius, after they had ousted him from Rome. It was the first time in Roman history that a general ordered his army to march against the Republic.

In 88 BC, Sulla was elected consul and given the command of the war against the king of Pontus Mithridates, who had recently invaded the Roman province of Asia. The same year, Sulla and his colleague Quintus Pompeius Rufus opposed the attempt of the tribune of the plebs Publius Sulpicius to enrol the Italians who received the Roman citizenship at the end of the Social War (91–87 BC). To bypass the consuls' opposition, Sulpicius sought the support of the popular Gaius Marius, who had already been consul six times. Marius demanded for his help that Sulpicius pass a law transferring Sulla's command to him. Using armed gangs to intimidate the tribal assembly, Sulpicius removed Pompeius' consulship and forced Sulla to flee from Rome, after which he enrolled the Italians and gave the Mithridatic command to Marius.

The conjoined representation of a star and a crescent is used in various historical contexts, including as a prominent symbol of the Ottoman Empire, and in contemporary times, as a national symbol by some countries, and by some Muslims as a symbol of Islam, while other Muslims reject it as an Islamic symbol. It was developed in the Greek colony of Byzantium ca. 300 BC, though it became more widely used as the royal emblem of Pontic king Mithridates VI Eupator after he incorporated Byzantium into his kingdom for a short period. During the 5th century, it was present in coins minted by the Persian Sassanian Empire; the symbol was represented in the coins minted across the empire throughout the Middle East for more than 400 years from the 3rd century until the fall of the Sassanians after the Muslim conquest of Persia in the 7th century. The conquering Muslim rulers kept the symbol in their coinage during the early years of the caliphate, as the coins were exact replicas of the Sassanian coins.

Both elements of the symbol have a long history in the iconography of the Ancient Near East as representing either the Sun and Moon or the Moon and Venus (Morning Star) (or their divine personifications). It has been suggested that the crescent actually represents Venus, or the Sun during an eclipse. Coins with star and crescent symbols represented separately have a longer history, with possible ties to older Mesopotamian iconography. The star, or Sun, is often shown within the arc of the crescent (also called star in crescent, or star within crescent, for disambiguation of depictions of a star and a crescent side by side). In numismatics in particular, the term pellet within crescent is used in cases where the star is simplified to a single dot.

The Mithridatic Wars were three conflicts fought between the Roman Republic and the Pontic kingdom of Mithridates VI Eupator. Fought across Greece and Asia Minor, the wars started in 88 BC and, while intermittent, only concluded with Mithridates' death in 63. The final settlement in 63 saw the Romans annex Pontus and Syria while also establishing a number of client kingdoms in Asia Minor.

Starting in 88 BC in the aftermath of the Asiatic Vespers, the first war was conducted by Lucius Cornelius Sulla, alongside and independent of Marian generals also assigned to the war, mainly in Greece and mostly concluded in 85 with the Treaty of Dardanos expelling Mithridates from the Aegean and forcing him to give up occupied territories in western Asia Minor. The second conflict lasted a few years in the late 80s BC and ended inconclusively.

The Asiatic Vespers (also known as the Asian Vespers, Ephesian Vespers, or the Vespers of 88 BC) refers to the massacres of Roman and other Latin-speaking peoples living in parts of western Anatolia c. early 88 BC by forces loyal to Mithridates VI Eupator, ruler of the Kingdom of Pontus, who orchestrated the massacre in an attempt to rid Asia Minor of Roman influence. An estimated 80,000 people were killed during the episode. The incident served as the casus belli or immediate cause of the First Mithridatic War between the Roman Republic and the Kingdom of Pontus. Some scholars and historians consider these massacres to be a case of genocide.

Mithridatism is the practice of protecting oneself against a poison by gradually self-administering non-lethal amounts. The word is derived from Mithridates VI, the king of Pontus, who so feared being poisoned that he regularly ingested small doses, aiming to develop immunity.