The Ministry of Defense (Arabic: وزارة الدفاع) is a cabinet ministry of Syria, responsible for defense affairs. Murhaf Abu Qasra, Minister of Defense holds the position of Deputy Commander-in-Chief of the Army and Armed Forces.
Following the fall of the regime of Bashar al-Assad in December 2024, caretaker prime minister Mohammed al-Bashir has said the defense ministry would be restructured using former rebel factions and officers who defected from the former Ba'athist armed forces.