Middle Danube in the context of "Dulebes"

Odoacer (c. 433 – 15 March 493 AD), also spelled Odovacer or Odovacar, was a barbarian soldier and statesman from the Middle Danube who was an officer of the Roman army and deposed the Western Roman child emperor Romulus Augustulus to become the ruler of Italy (476–493). Odoacer's overthrow of Romulus Augustulus is traditionally understood as marking the end of the Western Roman Empire.

Although he ruled Italy, Odoacer styled himself a client of the Eastern emperor Zeno in Constantinople. He was addressed not only as Latin: rex but also as dux and patrician, the latter title granted by Zeno. In the sole surviving document from his chancery—and by the consul Basilius—Odoacer used the title of king. Backed by the Roman Senate, he distributed land with little resistance. Soldier unrest in 477–478 caused violence, but his later reign was stable. Though an Arian, he seldom interfered in the Trinitarian state church.

The Lombards, Longobards or Langobards (Latin: Langobardi) were a Germanic people who conquered most of the Italian Peninsula between 568 and 774 AD. They had previously settled in the Middle Danube in the 5th century, near what is now Austria, Slovenia and Hungary. Their previous homeland was in the north, near present day Hamburg. Roman-era historians in the 1st and 2nd centuries AD mention the Lombards as one of the Suebian peoples, and report them living on the Lower Elbe already in the early 1st century. Their legacy is apparent in Lombardy, northern Italy, the region deriving its name from them.

There are no contemporary accounts of the Lombards in the 3rd or 4th century, or for most of the 5th century, which is when they reappear, near the Danube river far to the south. Legendary accounts of the Lombard migration are found in several early medieval texts, the oldest being the Origo Gentis Langobardorum (Origin of the Lombard People). There are two other notable later adaptions, the Chronicon Gothanum and the more scholarly History of the Lombards by Paul the Deacon, written between 787 and 796 AD, which contain more information. All three describe the Lombards as a people who moved to the Danube from somewhere near the North Sea. The details, however, differ until they enter "Rugiland" soon after Odoacer's defeat in 487/488 AD of the Rugii, who had a kingdom near what is now Vienna.

The Gepids (Latin: Gepidae, Gipedae; Ancient Greek: Γήπαιδες, romanized: Gḗpaides) were an East Germanic tribe who lived in the area of modern Romania, Hungary, and Serbia, roughly between the Tisza, Sava, and Carpathian Mountains. They were said to share the religion and language of the Goths and Vandals.

They are first mentioned by Roman sources in the third century. In the fourth century, they were among the peoples incorporated into the Hunnic Empire, within which they formed an important part. After the death of Attila, the Gepids under their leader Ardaric, led an alliance of other peoples who had been in the empire, and defeated the sons of Attila and their remaining allies at the Battle of Nedao in 454. The Gepids and their allies subsequently founded kingdoms on the Middle Danube, bordering on the Roman Empire. The Gepid Kingdom was one of the most important and long-lasting of these, centered on Sirmium, and sometimes referred to as Gepidia. It covered a large part of the former Roman province of Dacia, north of the Danube, and compared to other Middle Danubian kingdoms it remained relatively uninvolved with Rome.

The Lengyel culture is an archaeological culture of the European Neolithic, centered on the Middle Danube in Central Europe. It flourished from 5000 to 4000 BC, ending with phase IV, e.g., in Bohemia represented by the 'Jordanow/Jordansmühler culture'. It is followed by the Funnelbeaker culture/TrB culture and the Baden culture. The eponymous type site is at Lengyel in Tolna county, Hungary.