Mid-Missouri in the context of "Columbia, Missouri Metropolitan Area"

Columbia is a city in Boone County, Missouri, United States, and its county seat. It was founded in 1821 and had a population of 126,254 as recorded in the 2020 United States census, making it the fourth-most populous city in Missouri. Columbia is a Midwestern college town, home to the University of Missouri, a major research institution also known as MU or Mizzou. In addition to the university and surrounding Downtown Columbia are Stephens College and Columbia College, giving the city its educational focus and nearly 40,000 college students. It is the principal city of the Columbia metropolitan area, population 215,811, and the central city of the nine-county Columbia–Jefferson City–Moberly combined statistical area with 415,747 residents. The city is the fastest-growing municipality in Missouri, with a growth of almost 40% since 2000, and a population estimated at 130,900 in 2024. Columbia is among the most-educated cities in the United States with about half of citizens being college graduates and about a quarter holding advance degrees.

The city is built on the oak-forested hills and rolling prairies of Mid-Missouri, near the Missouri River, where the Ozark Mountains transition into plains and savanna. At the city's center is the Avenue of the Columns (8th Street), connecting Francis Quadrangle and Jesse Hall to the Boone County Courthouse and City Hall. Surrounding Columbia is a greenbelt including Rock Bridge Memorial State Park, Eagle Bluffs Conservation Area, the Mark Twain National Forest, Katy Trail State Park, Finger Lakes State Park, and the Big Muddy National Fish and Wildlife Refuge. Limestone bedrock forms bluffs and glades while rain dissolves the bedrock, creating karst (caves and springs) which water the Hinkson, Roche Perche, Flat Branch, and Bonne Femme creeks. Within city limits, there is an extensive city parks and trails system with a focus on non-motorized transportation, including the MKT Trail. The Columbia Agriculture Park is home to the nationally-regarded Columbia Farmers Market.

The Jefferson City metropolitan statistical area, as defined by the United States Census Bureau, is an area consisting of four counties – Cole, Callaway, Moniteau, and Osage – in central Missouri anchored by the city of Jefferson City. As of the 2020 census, the MSA had a population of 150,316. The Jefferson City MSA consists of four counties, and borders the Columbia metropolitan area to the north.

Boone County is located in the U.S. state of Missouri. Centrally located the state's Mid-Missouri region, its county seat is in Columbia, which is Missouri's fourth-largest city and location of the University of Missouri. As of the 2020 U.S. census, the county's population was listed as 183,610, making it the state's eighth-most populous county or county equivalent. The county was organized November 16, 1820, removed from the former larger Howard County (now to the northwest) of the old federal Missouri Territory of 1812-1821, and named for the famous Western explorer and settler of Kentucky, then recently deceased Daniel Boone (1734-1820), whose kin largely populated the Boonslick area, having arrived in the 1810s on the Boone's Lick Road.

Boone County comprises the Columbia Metropolitan Area. The towns of Ashland and Centralia are the second and third most populous towns in the county.

The University of Missouri (Mizzou or MU) is a public land-grant research university in Columbia, Missouri, United States. It is Missouri's largest university and the flagship of the four-campus University of Missouri System. Founded in 1839, MU was the first public university west of the Mississippi River. It has been a member of the Association of American Universities since 1908 and is classified among "R1: Doctoral Universities – Very high research activity."

Enrolling 31,041 students in 2023, it offers more than 300 degree programs in thirteen major academic divisions. Its Missouri School of Journalism, founded by Walter Williams in 1908, was established as the world's first journalism school; it publishes a daily newspaper, the Columbia Missourian, and operates NBC affiliate KOMU. The University of Missouri Research Reactor Center is the sole source of isotopes in nuclear medicine in the United States. The university operates University of Missouri Health Care, running several hospitals and clinics in Mid-Missouri.

The Columbia metropolitan area is the region centered around the City of Columbia in the U.S. state of Missouri. Located in Mid-Missouri, it consists of five counties: Boone, Audrain, Randolph, Cooper, and Howard. The population was estimated at 256,640 in 2017, making it the 4th largest metropolitan area in Missouri. Columbia is home to the University of Missouri, and is Missouri's fourth most-populous and fastest growing city, with an estimated 121,717 residents as of 2017. Other significant cities in the area include Moberly, Mexico, Boonville, Vandalia, Centralia, and Fayette. There is also a 9-county Columbia–Jefferson City–Moberly combined statistical area with 415,747 residents.

The area was originally called the Boonslick and settled mainly by Kentuckians following the Boone's Lick Road starting around 1812. The town of Franklin, now washed into the Missouri River, was an early commercial center and start of the Santa Fe Trail. Columbia was founded as county seat of Boone County in 1821. The region was considered for the location of the Missouri State Capitol, but eventually a site was chosen 30 miles (48 km) south of Columbia and Jefferson City was created to serve that purpose. Today, Interstate 70, and U.S. Highways 63, 54, 24, and 40 link the urban areas. The U.S. census defines the Columbia MSA as Boone, Cooper, and Howard counties while the addition of the Jefferson City MSA along with Audrain and Randolph form the combined statistical area.