Microenvironment (biology) in the context of "Spatial biology"

Spatial biology is the study of biomolecules and cells in their native three-dimensional context. Spatial biology encompasses different levels of cellular resolution including (1) subcellular localization of DNA, RNA, and proteins, (2) single-cell resolution and in situ communications like cell-cell interactions and cell signaling, (3) cellular neighborhoods, regions, or microenvironments, and (4) tissue architecture and organization in organs. Dysregulation of tissue organization is a common feature in human disease progression including tumorigenesis and neurodegeneration. Many fields within biology are studied for their individual contribution to spatial biology.