Mickey Mouse (comic strip) in the context of "Floyd Gottfredson"

Mickey Mouse is a cartoon character co-created in 1928 by Walt Disney and Ub Iwerks. The longtime icon and mascot of the Walt Disney Company, Mickey is an anthropomorphic mouse who typically wears red shorts, large shoes, and white gloves. He is often depicted with a cast of characters including his girlfriend Minnie Mouse, his pet dog Pluto, his best friends Donald Duck and Goofy, and his nemesis Pete.

Mickey was created as a replacement for a prior Disney character, Oswald the Lucky Rabbit. The character was originally to be named "Mortimer Mouse", until Disney's wife, Lillian, suggested "Mickey". Mickey first appeared in two 1928 shorts Plane Crazy and The Gallopin' Gaucho (which were not picked up for distribution) before his public debut in Steamboat Willie (1928). The character went on to appear in over 130 films, mostly shorts as well as features such as Fantasia (1940). Since 1930, Mickey has been featured extensively in comic strips (including the Mickey Mouse comic strip, which ran for 45 years) and comic books (such as Mickey Mouse). The character has also been featured in television series such as The Mickey Mouse Club (1955–1996).

The Mickey Mouse universe is a fictional shared universe which is the setting for stories involving Disney cartoon characters, including Mickey and Minnie Mouse, Donald and Daisy Duck, Goofy and Pluto as the primary members (colloquially known as the "Sensational Six"), and many other characters related to them, most of them being anthropomorphic animals. The universe originated from the Mickey Mouse animated short films produced by Disney starting in 1928, although its first consistent version was created by Floyd Gottfredson in the Mickey Mouse newspaper comic strip. Real-world versions also exist in Disneyland and Tokyo Disneyland, called Mickey's Toontown. The term "Mickey Mouse universe" is not officially used by The Walt Disney Company, but it has been used by Disney comics author and animation historian David Gerstein. The Walt Disney Company typically uses terms such as Mickey & Friends or Mickey & the Gang to refer to the character franchise.

Since 1990, the city in which Mickey lives is typically called Mouseton in American comics. In modern continuity, Mouseton is often depicted as being located in the fictional U.S. state of Calisota, analogous to Northern California. This fictional state was invented by comics writer Carl Barks in 1952 as the location for Donald Duck's home city, Duckburg.

Mickey Mouse (briefly Mickey Mouse and Friends) is a Disney comic book series that has a long-running history, first appearing in 1943 as part of the Four Color one-shot series. It received its own numbering system with issue #28 (December 1952).

The book emphasizes stories with Mickey and his supporting cast: Goofy, Donald Duck, Minnie Mouse, Pluto and Mickey's nephews Morty and Ferdie Fieldmouse. Mickey's perpetual rival is the criminal Peg-Leg Pete (sometimes "Black Pete", "Sneaky Pete" or "Big Bad Pete"). Other adversaries have included Emil Eagle, Eli Squinch, Sylvester Shyster, the team of Dangerous Dan McBoo and Idjit the Midget, and the Phantom Blot. Two major artistic influences on the appearance of Mickey in comics are Floyd Gottfredson, who drew the Mickey Mouse comic strip from 1930 to 1975, and comic book artist Paul Murry, who drew Mickey stories from 1950 to 1984.

Disney comics are comic books and comic strips featuring characters created by the Walt Disney Company, including Mickey Mouse, Donald Duck, Goofy, Scrooge McDuck and José Carioca.

The first Disney comics were newspaper strips appearing from 1930 on, starting with the Mickey Mouse comic strip. Mickey Mouse Magazine, the first American newsstand publication with Disney comics, launched in 1935. In 1940, Western Publishing launched the long-running flagship comic book, Walt Disney's Comics and Stories, which reached 750 issues in September 2019. Uncle Scrooge, launched in 1952, reached issue #450 in June 2019. In recent decades, Disney comics have seen a decline of popularity in the United States. In the rest of the world Disney comics have remained very successful, especially in Europe, where weekly Disney comics magazines and monthly paperback digests are national best sellers.