Irene Komnene Doukaina or Eirene Komnene Doukaina (Greek: Ειρήνη Κομνηνή Δούκαινα, Bulgarian: Ирина Комнина Дукина) was an Empress of Bulgaria during the Second Bulgarian Empire and Byzantine princess. She was the third wife of tsar Ivan Asen II of Bulgaria. She was the mother of tsar Michael Asen I of Bulgaria.
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