In Roman mythology, Mefitis (or Mephitis; Mefite in Italian) was a goddess of Italic origins primarily worshipped by the Samnites and Osci in southern Italy. Mefitis was associated with water— particularly foul-smelling or sulfurous water— and noxious fumes. Her main temple was situated near Lake Ampsanctus, which was described as deadly by Cicero and Pliny. The temple itself was reported to contain poisonous gas that killed anyone who entered, and Virgil described it as an entrance to the underworld.
Though Mefitis is sometimes cast as the goddess of intoxication, modern scholarship generally disagrees with this assertion. Modern scholars have proposed that Mefitis served a medicinal role due to her association with sulfur, which Romans considered purifying; an agricultural role due to her epithet Aravinna, from arva ("soil"); or a mediatory role, with her sacred sites believed to serve as links between the heavens and the underworld.