Medical drama in the context of "House (TV series)"

Gregory House is a fictional character and the titular protagonist of the American medical drama series House. Created by David Shore and portrayed by English actor Hugh Laurie, he leads a team of diagnosticians and is the Head of Diagnostic Medicine at the fictional Princeton-Plainsboro Teaching Hospital in Princeton, New Jersey. House's character has been described as a misanthrope, cynic, narcissist, and curmudgeon.

In the series, the character's unorthodox diagnostic approaches, radical therapeutic motives, and stalwart rationality have resulted in much conflict between him and his colleagues. House is also often portrayed as lacking sympathy for his patients, a practice that allows him time to solve ethical enigmas. The character is partly based on Sherlock Holmes. A portion of the show's plot centers on House's habitual use of Vicodin to manage pain stemming from leg infarction involving his quadriceps muscle some years earlier, an injury that forces him to walk with a cane. This dependency is also one of the many parallels to Holmes, who is portrayed as being a habitual user of cocaine and other drugs.

Lisa Cuddy, M.D., is a fictional character on the medical drama House. She is portrayed by Lisa Edelstein. Cuddy was the dean of medicine of the fictional Princeton-Plainsboro Teaching Hospital in New Jersey. Cuddy quit her job after the events of season seven's finale "Moving On".

James Evan Wilson, M.D., is a fictional character on the medical drama House. He is played by Robert Sean Leonard. The character first appears in the show's pilot episode when he introduces a medical case to the protagonist, Dr. Gregory House. Wilson is Dr. House's only true friend; Wilson frequently provides House with consultations and aid. Wilson is the head of the Department of Oncology at Princeton-Plainsboro Teaching Hospital.

During the show's run, the characters of House and Wilson have been compared to Sherlock Holmes and Dr. Watson. Wilson's portrayer, Robert Sean Leonard, has stated that his character and Dr. House were originally supposed to play these roles, but that Dr. House's diagnostic team has taken over Dr. Watson's part. Leonard also read the script of the pilot episode of CBS' Numb3rs and planned to audition. He auditioned for Wilson instead because he felt he would more enjoy playing the character that House went to for help and because he liked the Odd Couple dynamic of the relationship.

Allison Cameron, M.D., is a fictional character on the medical drama House, portrayed by American actress Jennifer Morrison. An immunologist, Cameron is a member of Dr. Gregory House's team of handpicked specialists at Princeton–Plainsboro Teaching Hospital's Department of Diagnostic Medicine. She returns for the final episode of the series, "Everybody Dies". She is Board Certified in Immunology and Internal Medicine as seen on a computer in Season 1.

Omar Hashim Epps (born July 20, 1973) is an American actor, rapper, and producer. Epps's film roles include Juice, Higher Learning, The Wood, In Too Deep, and Love & Basketball. His television work includes the role of Dr. Dennis Gant on the medical drama series ER, J. Martin Bellamy in Resurrection, Dr. Eric Foreman on the Fox medical drama series House from 2004 to 2012, Isaac Johnson in the TV series Shooter from 2016 to 2018, and Detective Malcolm Howard on the Starz crime drama Power Book III: Raising Kanan. He has been awarded nine NAACP Image Awards, two Teen Choice Awards, one MTV Movie Award, one Black Reel Award, and one Screen Actors Guild Award.

Remy "Thirteen" Hadley, M.D., is a fictional character on the medical drama House, portrayed by Olivia Wilde. She is part of the new diagnostic team assembled by Dr. Gregory House after the disbanding of his previous team in the third-season finale. The character's nickname derives from the episode "The Right Stuff", when she is assigned the number during a competition for her position at the Princeton-Plainsboro Teaching Hospital.

The show depicts Thirteen as a secretive character who does not divulge personal information; her surname was not used on the show until the fourth season's penultimate episode "House's Head", nor her given name until the fifth-season episode "Emancipation". Instead, several of the character's traits are implied before they are depicted as true. In the season four episode "You Don't Want to Know", Thirteen tells House that her mother died from Huntington's disease; a test she performs several episodes later confirms she carries the gene. After hints were given regarding her character's sexuality, Wilde confirmed that her character is indeed bisexual. This is confirmed by Eric Foreman in the episode "Don't Ever Change".