Massachusetts General Hospital in the context of "Shiladitya DasSarma"

Klinefelter syndrome (KS), also known as 47,XXY, is a chromosome anomaly where a male has an extra X chromosome. The complications commonly include infertility and small, poorly functioning testicles (if present). These symptoms are often noticed only at puberty, although this is one of the most common chromosomal disorders. The birth prevalence of KS in the State of Victoria, Australia was estimated to be 223 per 100,000 males. It is named after American endocrinologist Harry Klinefelter, who identified the condition in the 1940s, along with his colleagues at Massachusetts General Hospital.

The syndrome is defined by the presence of at least one extra X chromosome in addition to a Y chromosome, yielding a total of 47 or more chromosomes rather than the usual 46. Klinefelter syndrome occurs randomly. The second X chromosome comes from the father and mother nearly equally. An older mother may have a slightly increased risk of a child with KS. The syndrome is diagnosed by the genetic test known as karyotyping.

McLean Hospital (/məkˈleɪn/) (formerly known as Somerville Asylum and Charlestown Asylum) is a psychiatric hospital in Belmont, Massachusetts. McLean maintains the world's largest neuroscientific and psychiatric research program in a private hospital. It is the largest psychiatric facility of Harvard Medical School, an affiliate of Massachusetts General Hospital, and part of Mass General Brigham, which also includes Brigham and Women's Hospital.

Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of Johns Hopkins School of Medicine in Baltimore, Maryland. Founded in 1889, Johns Hopkins Hospital and its school of medicine are considered to be the founding institutions of modern American medicine and the birthplace of numerous famed medical traditions, including rounds, residents, and house staff. Several medical specialties were founded at the hospital, including neurosurgery by Harvey Cushing and Walter Dandy, cardiac surgery by Alfred Blalock and Vivien Thomas, and child psychiatry by Leo Kanner. Johns Hopkins Children's Center, which serves infants, children, teens, and young adults aged 0–21, is attached to the hospital.

Johns Hopkins Hospital is widely regarded as one of the world's greatest hospitals and medical institutions. For 21 consecutive years from 1991 to 2020, it was ranked as the best overall hospital in the United States by U.S. News & World Report. In its 2019–2020 edition, U.S. News & World Report ranked the hospital on 15 adult specialties and 10 children's specialties; the hospital came in 1st in Maryland and third nationally behind the Mayo Clinic in Rochester, Minnesota and Massachusetts General Hospital in Boston. In 2021, the hospital marked 32 consecutive years of placing in the top five hospitals in the nation.

Harvard Medical School (HMS) is the medical school of Harvard University. It is located in the Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the United States. It provides patient care, medical education, and research training through its 15 clinical affiliates and research institutes, including Massachusetts General Hospital (MGH), Boston Children's Hospital, Dana–Farber Cancer Institute, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Mount Auburn Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, Spaulding Rehabilitation Hospital, and others.

Harvard Medical School also partners with newer entities such as Harvard Catalyst, Broad Institute of MIT and Harvard, Harvard Stem Cell Institute, the Center for Primary Care, and Wyss Institute for Biologically Inspired Engineering.