Chambersburg is a borough in and the county seat of Franklin County, in the South Central region of Pennsylvania, United States. It is in the Cumberland Valley, which is part of the Great Appalachian Valley, and 13 miles (21Â km) north of Maryland and the Mason-Dixon line and 52 miles (84Â km) southwest of Harrisburg, the state capital. According to the United States Census Bureau, Chambersburg's 2020 population was 21,903. When combined with the surrounding Greene, Hamilton, and Guilford Townships, the population of Greater Chambersburg is 66,340 people. The Chambersburg, PA Metropolitan Statistical Area includes surrounding Franklin County, and in 2010 included 149,618 people.
According to the Pennsylvania Department of Community and Economic Development, Chambersburg Borough is the thirteenth-largest municipality in Pennsylvania and the largest borough as measured by fiscal size as of 2016. Chambersburg Borough is organized under the Pennsylvania Borough Code and is not a home-rule municipality.