Yusuf Sayfa Pasha (Arabic: يوسف سيفا باشا, romanized: Yūsuf Sayfā Pāsha; c. 1510 – 22 July 1625) was a chieftain and multazim (tax farmer) in the Tripoli region who frequently served as the Ottoman beylerbey (provincial governor) of Tripoli Eyalet between 1579 and his death.
Yusuf or his family may have been Kurdish or Turkmen levends (tribal irregulars) from Marash and were established in Tripoli's vicinity by at least the 1510s–1520s. He became a multazim in Akkar subordinate to the Assaf chieftains of the Keserwan for most of his career until his promotion to the rank of pasha and appointment as Tripoli's first beylerbey in 1579. Hostilities consequently ensued with the Assafs, ending with Yusuf's assassination of their last chieftain in 1591 and his confiscation of their tax farms. His takeover of the Keserwan and Beirut prompted his first confrontation with Fakhr al-Din II, the Druze chieftain and sanjak-bey (district governor) of Sidon-Beirut in 1598. He was given command by the Sublime Porte (Ottoman imperial government) over the armies in the region of Syria to suppress the rebel Ali Janbulad of Aleppo in 1606. After a series of defeats at Hama, Tripoli and Damascus, he submitted to Janbulad at Krak des Chevaliers (Hisn al-Akrad), though the rebellion was suppressed in 1607.