Malta (island) in the context of "Regions of Europe"

The Grand Master of the Order of St John of Jerusalem had to pay an annual tribute to the Emperor Charles V and his mother Queen Joanna of Castile as monarchs of Sicily, for the granting of Tripoli, Malta and Gozo. There were also other conditions. The annual tribute payable on All Saints day (1 November) was one falcon. The grant was made at Castelfranco Emilia and is dated "the 23rd day of the month of March, Third Indiction, in the Year of Our Lord 1530; in the 10th year of our reign as Emperor, the 27th as King of Castile, Granada etc., the 16th of Navarre, the 15th of Aragon, the Two Sicilies, Jerusalem and all our other realms".

Hospitaller Malta, known in Maltese history as the Knights' Period (Maltese: Żmien il-Kavallieri, lit. 'Time of the Knights'), was a de facto state which existed between 1530 and 1798 when the Mediterranean islands of Malta and Gozo were ruled by the Order of St. John of Jerusalem. It was formally a vassal state of the Kingdom of Sicily, and it came into being when Emperor Charles V granted the islands as well as the city of Tripoli in modern Libya to the Order, following the latter's loss of Rhodes in 1522. Hospitaller Tripoli was lost to the Ottoman Empire in 1551, but an Ottoman attempt to take Malta in 1565 failed.

Following the 1565 siege, the Order decided to settle permanently in Malta and began to construct a new capital city, Valletta. For the next two centuries, Malta went through a Golden Age, characterized by a flourishing of the arts, architecture, and an overall improvement in Maltese society. In the mid-17th century, the Order was the de jure proprietor over some islands in the Caribbean, making it the smallest state to colonize the Americas.

The 1813–1814 Malta plague epidemic (Maltese: l-epidemija tal-pesta tal-1813–1814) was the last major outbreak of plague on the islands of Malta and Gozo. It occurred between March 1813 and January 1814 on Malta and between February and May 1814 on Gozo, and the epidemic was officially declared to be over in September 1814. It resulted in approximately 4500 deaths, which was about 5% of the islands' population.

The plague outbreak had begun in Constantinople in 1812 and it spread to other parts of the Ottoman Empire, including Egypt. The disease was imported to Malta from Alexandria on board the brigantine San Nicola in late March 1813. Some of its crew members had contracted the disease and died, and although the vessel and crew were quarantined, the disease spread to the local population since infected cargo from the vessel was stolen and sold in Valletta. The disease appeared in the city in mid-April, and the outbreak was severe by mid-May.

Tripoli, today the capital city of Libya, was ruled by the Knights Hospitaller between 1530 and 1551. The city had been under Spanish rule for two decades before it was granted as a fief to the Hospitallers in 1530 along with the islands of Malta and Gozo. The Hospitallers found it difficult to control both the city and the islands, and at times they proposed to either move their headquarters to Tripoli or to abandon and raze the city. Hospitaller rule over Tripoli ended in 1551 when the city was captured by the Ottoman Empire following a siege.

The Port Region (Maltese: Reġjun tal-Port) is one of the six regions of Malta. The region is located in the southeastern part of the main island of Malta. The region borders the Eastern and Southern Regions.

It was created by the Act No. XIV of 2019 out of part of the South Eastern Region, and became effective in 2022.

The Victoria Lines, originally known as the North West Front, are a line of fortifications that spans 12 kilometres along the width of Malta, dividing the north of the island from the more heavily populated south.