Maipo River in the context of "Valparaíso Region"

Inca rule in Chile was brief, lasting from the 1470s to the 1530s when the Inca Empire was absorbed by Spain. The main settlements of the Inca Empire in Chile lay along the Aconcagua, Mapocho and Maipo rivers. Quillota in Aconcagua Valley was likely the Incas' foremost settlement. The bulk of the people conquered by the Incas in Central Chile were Diaguitas and part of the Promaucae (also called Picunches). Incas appear to have distinguished between a "province of Chile" and a "province of Copayapo" neighboring it to the north. In Aconcagua Valley the Incas settled people from the areas of Arequipa and possibly also the Lake Titicaca.

Promaucae, also spelled as Promaucas or Purumaucas (from Quechua purum awqa: wild enemy), were an Indigenous pre-Columbian Mapuche tribal group that lived in the present territory of Chile, south of the Maipo River basin of Santiago, Chile and the Itata River. Those to the north were called Quillotanes and Mapochoes by the Spanish colonists). They spoke Mapudungun, like the Moluche to the south, and were part of the Picunche tribe that lived north of the Itata River.