Lake Titicaca in the context of "Incas in Central Chile"

The Tiwanaku polity (Spanish: Tiahuanaco or Tiahuanacu) was a Pre-Columbian polity in western Bolivia based in the southern Lake Titicaca Basin. Tiwanaku was one of the most significant Andean civilizations. Its influence extended into present-day Peru and Chile and lasted from around 600 to 1000. Its capital was the monumental city of Tiwanaku, located at the center of the polity's core area in the southern Lake Titicaca Basin. This area has clear evidence for large-scale agricultural production on raised fields that probably supported the urban population of the capital. Researchers debate whether these fields were administered by a bureaucratic state (top-down) or through a federation of communities with local autonomy (bottom-up; see review of debate in Janusek 2004:57-73). Tiwanaku was once thought to be an expansive military empire, based mostly on comparisons to the later Inca Empire. However, recent research suggests that labelling Tiwanaku as an empire or even a state may be misleading. Tiwanaku is missing a number of features traditionally used to define archaic states and empires: there is no defensive architecture at any Tiwanaku site or changes in weapon technology, there are no princely burials or other evidence of a ruling dynasty or a formal social hierarchy, no evidence of state-maintained roads or outposts, and no markets.

Tiwanaku was a multi-cultural network of powerful lineages that brought people together to build large monuments. These work feasts integrated people in powerful ceremonies, and this was probably the central dynamic that attracted people from hundreds of kilometers away, who may have traveled there as part of llama caravans to trade, make offerings, and honor the gods. Tiwanaku grew into the Andes' most important pilgrimage destination and one of the continent's largest Pre-Columbian cities, reaching a maximum population of 10,000 to 20,000 around 800.

Quinoa (Chenopodium quinoa; /ˈkiːn.wɑː, kiˈnoʊ.ə/, from Quechua kinwa or kinuwa) is a flowering plant in the amaranth family. It is a herbaceous annual plant grown as a crop primarily for its edible seeds; the seeds are high in protein, dietary fiber, B vitamins and dietary minerals especially potassium and magnesium in amounts greater than in many grains. Quinoa is not a grass but rather a pseudocereal botanically related to spinach and amaranth (Amaranthus spp.), and originated in the Andean region of northwestern South America. It was first used to feed livestock 5,200–7,000 years ago, and for human consumption 3,000–4,000 years ago in the Lake Titicaca basin of Bolivia and Peru.

The plant thrives at high elevations and produces seeds that are rich in protein. Almost all production in the Andean region is done by small farms and associations. Its cultivation has spread to more than 70 countries, including Kenya, India, the United States, and European countries. As a result of increased consumption in North America, Europe, and Australasia, quinoa crop prices tripled between 2006 and 2014, entering a boom and bust cycle.

La Paz (Spanish: [la ˈpas]; lit. 'the peace'), officially Nuestra Señora de La Paz (Aymara: Chuqi Yapu Aymara pronunciation: [ˈtʃoqɛ ˈjapʊ]), is the seat of government of Bolivia. With 755,732 residents as of 2024, it is the third-most populous city in Bolivia. Its metropolitan area, which includes the neighboring city of El Alto, and other smaller towns, is the second most populous urban area in Bolivia, with a population of 2.2 million, after Santa Cruz de la Sierra with a population of 2.3 million. The city is also the capital of the department of the same name.

Located in west-central Bolivia 68 km (42 mi) southeast of Lake Titicaca, La Paz is set in a canyon created by the Choqueyapu River. It is in a bowl-like depression, part of the Amazon basin, surrounded by the high mountains of the Altiplano. Overlooking the city is the triple-peaked Illimani. Its peaks are always snow-covered and can be seen from many parts of the city. At an elevation of roughly 3,650 m (11,975 ft) above sea level, La Paz is the highest administrative capital city in the world. Due to its altitude, the city has an unusual subtropical highland climate, with rainy summers and dry winters.

The geography of Bolivia includes the Eastern Andes Mountain Range (also called the Cordillera Oriental) which bisects Bolivia roughly from north to south. To the east of that mountain chain are lowland plains of the Amazon Basin, and to the west is the Altiplano which is a highland plateau where Lake Titicaca is located. Bolivia's geography has features similar to those of Peru which abuts Bolivia's northwest border; like Bolivia, Peru is bisected from north to south by the Eastern Andes Mountains, and these two countries share Lake Titicaca which is the highest navigable lake on Earth. Unlike Peru, however, Bolivia is one of the two landlocked countries in South America, the other being Paraguay, which is located along Bolivia's southeast border.

The languages of Bolivia include Spanish and several dozen indigenous languages, most prominently Aymara, Quechua, Chiquitano, Guaraní and the Bolivian Sign Language (closely related to the American Sign Language). Indigenous languages and Spanish are official languages of the state according to the 2009 Constitution. The constitution says that all indigenous languages are official, listing 36 specific indigenous languages, of which some are extinct. Spanish and Quechua are spoken primarily in the Andes region, Aymara is mainly spoken in the Altiplano around Lake Titicaca, Chiquitano is spoken in the central part of Santa Cruz department, and Guarani is spoken in the southeast on the border with Paraguay and Argentina.

The Altiplano (Spanish for "high plain"), Collao (Quechua and Aymara: Qullaw, meaning "place of the Qulla") or Andean Plateau, in west-central South America, is the most extensive high plateau on Earth outside Tibet. The plateau is located at the latitude of the widest part of the north–south-trending Andes. The bulk of the Altiplano lies in Bolivia, but its northern parts lie in Peru, its southwestern fringes lie in Chile, and it extends into Argentina.

Many towns and several cities are on the plateau, including El Alto and Oruro in Bolivia and Juliaca and Puno in Peru. The northeastern part of the Altiplano is more humid than the southwestern part, which has several salares (salt flats), due to its aridity. At the Bolivia–Peru border lies Lake Titicaca, the largest lake in South America. Farther south, in Bolivia, Lake Poopó existed until recently, but by December 2015, it had completely dried up, and was declared defunct. Whether that lake, which had been the second-largest in Bolivia, can be restored is unclear.

The Ucayali River (Spanish: Río Ucayali, IPA: [ˈri.o wkaˈʝali]) is the main headstream of the Amazon River. It rises about 110 km (68 mi) north of Lake Titicaca, in the Arequipa region of Peru and becomes the Amazon at the confluence of the Marañón close to Nauta city. The city of Pucallpa is located on the banks of the Ucayali.

The Wari (Spanish: Huari) were a Middle Horizon civilization that flourished in the south-central Andes and coastal area of modern-day Peru, from about 500 to 1000 AD. At their height, they formed the Wari Empire.

Wari, as the former capital city was called, is located 11 km (6.8 mi) north-east of the modern city of Ayacucho, Peru. This city was the center of a civilization that covered much of the highlands and coast of modern Peru. The best-preserved remnants, besides the Huari|Wari ruins, are the recently discovered Northern Wari ruins near the city of Chiclayo, and Cerro Baúl in Moquegua. Also well-known are the Wari ruins of Pikillaqta ("Flea Town"), a short distance south-east of Cuzco en route to Lake Titicaca.