Maipo River in the context of Mouth bar

Inca rule in Chile was brief, lasting from the 1470s to the 1530s when the Inca Empire was absorbed by Spain. The main settlements of the Inca Empire in Chile lay along the Aconcagua, Mapocho and Maipo rivers. Quillota in Aconcagua Valley was likely the Incas' foremost settlement. The bulk of the people conquered by the Incas in Central Chile were Diaguitas and part of the Promaucae (also called Picunches). Incas appear to have distinguished between a "province of Chile" and a "province of Copayapo" neighboring it to the north. In Aconcagua Valley the Incas settled people from the areas of Arequipa and possibly also the Lake Titicaca.

Promaucae, also spelled as Promaucas or Purumaucas (from Quechua purum awqa: wild enemy), were an Indigenous pre-Columbian Mapuche tribal group that lived in the present territory of Chile, south of the Maipo River basin of Santiago, Chile and the Itata River. Those to the north were called Quillotanes and Mapochoes by the Spanish colonists). They spoke Mapudungun, like the Moluche to the south, and were part of the Picunche tribe that lived north of the Itata River.

The Picunche (a Mapudungun word meaning "North People"), also referred to as picones by the Spanish, were a Mapudungun-speaking people living to the north of the Mapuches or Araucanians (a name given to those Mapuche living between the Itata and Toltén rivers) and south of the Choapa River and the Diaguitas. Until the Conquest of Chile the Itata was the natural limit between the Mapuche, located to the south, and Picunche, to the north. During the Inca attempt to conquer Chile the southern Picunche peoples that successfully resisted them were later known as the Promaucaes.

The Picunche living north of the Promaucaes were called Quillotanes (those living in the Aconcagua River valley north to the Choapa) and Mapochoes (those living in the Maipo River basin) by the Spanish, and were part of the Inca Empire at the time when the first Spaniards arrived in Chile.