South Waziristan District (Urdu: ضلع جنوبی Ù…Øسود وزیرستان) was a district in the Dera Ismail Khan Division of the Khyber Pakhtunkhwa province of Pakistan, before splitting into the Lower South Waziristan District and the Upper South Waziristan District on 13 April 2022. South Waziristan was located in the southwest of Khyber Pakhtunkhwa. It was situated between two rivers, the Tochi River to the north and the Gomal River to the south. In 1894 the Mahsud tribe under Mulla Powinda, who assumed the title Badshah-i-Taliban, attacked at Wana which led to an expedition by the British against the tribes during the cold season of 1894-1895, following on from this the agency of South Waziristan had been created with its headquarters at Wanna.
South Waziristan was dominated by the Wazir tribe while North Waziristan was dominated by the Mahsud tribe, both the tribes are the subgroups of the Waziri tribe, after whom the region "Waziristan" is named, and speak a common Waziristani dialect.