Tiberius Sempronius Longus (c. 260 BC – unknown) was a Roman consul during the Second Punic War and a contemporary of Publius Cornelius Scipio (father of Scipio Africanus). In 219 BC, Sempronius and the elder Scipio were elected as consuls for 218 BC. At the outbreak of the war in 218 BC, he was ordered to conduct the war effort in Sicily and Africa, while Scipio was sent to the Iberian Peninsula to attack Hannibal himself. Sempronius was allocated two Roman legions, 16,000 allied infantry, 1,800 allied cavalry, 160 quinqueremes and 20 lighter vessels. As soon as his army was assembled he moved his forces to Sicily. Striking from Lilybaeum Sempronius captured Malta from the Carthaginians.
Shortly thereafter, with Scipio wounded and pursued by Hannibal's forces after the Battle of Ticinus, the Senate sent for Tiberius Sempronius Longus. Upon his arrival in December, and reportedly against Scipio's advice, Sempronius Longus led an ambitious attack at the Battle of the Trebia. His army charged into a trap and was enveloped by the forces of Hannibal's brother, Mago. Although it was a crushing Roman defeat, Tiberius Sempronius Longus and a force of 10,000 infantrymen fought their way through the rear Carthaginian lines and to safety.