Ludovico Sforza in the context of "Regency"

Leonardo di ser Piero da Vinci (15 April 1452 – 2 May 1519) was an Italian polymath of the High Renaissance who was active as a painter, draughtsman, engineer, scientist, theorist, sculptor, and architect. While his fame initially rested on his achievements as a painter, he has also become known for his notebooks, in which he made drawings and notes on a variety of subjects, including anatomy, astronomy, botany, cartography, painting, and palaeontology. Leonardo is widely regarded to have been a genius who epitomised the Renaissance humanist ideal, and his collective works comprise a contribution to later generations of artists matched only by that of his younger contemporary Michelangelo.

Born out of wedlock to a successful notary and a lower-class woman in, or near, Vinci, he was educated in Florence by the Italian painter and sculptor Andrea del Verrocchio. He began his career in the city, but then spent much time in the service of Ludovico Sforza in Milan. Later, he worked in Florence and Milan again, as well as briefly in Rome, all while attracting a large following of imitators and students. Upon the invitation of Francis I, he spent his last three years in France, where he died in 1519. Since his death, there has not been a time when his achievements, diverse interests, personal life, and empirical thinking have failed to incite interest and admiration, making him a frequent namesake and subject in culture.

The Italian polymath Leonardo da Vinci (1452–1519) left thousands of pages of writings and drawings but rarely made any references to his personal life. The resulting uncertainty, combined with mythologized anecdotes from his lifetime, has resulted in much speculation and interest in Leonardo's personal life. His personal relationships, philosophy, religion, vegetarianism, left-handedness, and appearance have all been topics of fascination.

Leonardo has long been regarded as the archetypal Renaissance man, described by the Renaissance biographer Giorgio Vasari as having qualities that "transcended nature" and being "marvellously endowed with beauty, grace and talent in abundance". Interest in and curiosity about Leonardo has continued unabated for five hundred years. Modern descriptions and analysis of Leonardo's character, personal desires, and intimate behaviour have been based upon various sources: records concerning him, his biographies, his own written journals, his paintings, his drawings, his associates, and commentaries that were made concerning him by contemporaries.

The Last Supper (Italian: Il Cenacolo [il tʃeˈnaːkolo] or L'Ultima Cena [ˈlultima ˈtʃeːna]) is a mural painting by the Italian High Renaissance artist Leonardo da Vinci, dated to c. 1495–1498, housed in the refectory of the Convent of Santa Maria delle Grazie in Milan, Italy. The painting represents the scene of the Last Supper of Jesus with the Twelve Apostles, as it is told in the Gospel of John – specifically the moment after Jesus announces that one of his apostles will betray him. Its handling of space, mastery of perspective, treatment of motion and complex display of human emotion has made it one of the Western world's most recognizable paintings and among Leonardo's most celebrated works. Some commentators consider it pivotal in inaugurating the transition into what is now termed the High Renaissance.

The work was commissioned as part of a plan of renovations to the church and its convent buildings by Leonardo's patron Ludovico Sforza, Duke of Milan. In order to permit his inconsistent painting schedule and frequent revisions, it is painted with materials that allowed for regular alterations: tempera on gesso, pitch, and mastic. Due to the methods used, a variety of environmental factors, and intentional damage, little of the original painting remains today despite numerous restoration attempts, the last being completed in 1999. The Last Supper is Leonardo's largest work, aside from the Sala delle Asse.

The Italian Wars were a series of conflicts fought between 1494 and 1559, mostly in the Italian Peninsula, later expanding into Flanders, the Rhineland and Mediterranean Sea. The primary belligerents were the Valois kings of France, on one side, and their Habsburg opponents in the Holy Roman Empire and Spain on the other. Numerous Italian states participated at different stages, some on both sides, with limited involvement from England, and the Ottoman Empire.

The 1454 Italic League achieved a balance of power in Italy, but disintegrated after the death of its chief architect, Lorenzo de' Medici, in 1492. Combined with the ambition of Ludovico Sforza, its collapse allowed Charles VIII of France to invade Naples in 1494, which drew in Spain and the Holy Roman Empire. Although Charles was forced to withdraw in 1495, ongoing political divisions among the Italian states made them a battleground in the struggle for European domination between France and the Habsburgs.

The Lady with an Ermine is a portrait painting by the Italian Renaissance artist Leonardo da Vinci. Dated to c. 1489–1491, the work is painted in oils on a panel of walnut wood. Its subject is Cecilia Gallerani, a mistress of Ludovico Sforza ("Il Moro"), Duke of Milan; Leonardo was painter to the Sforza court in Milan at the time of its execution. It is the second of only four surviving portraits of women painted by Leonardo, the others being Ginevra de' Benci, La Belle Ferronnière and the Mona Lisa.

Lady with an Ermine is now housed at the Czartoryski Museum in Kraków, and is one of Poland's national treasures. It is part of the Princes Czartoryski Collection, which was sold for €100 million (5% of the estimated market value of the entire collection) on 29 December 2016 to the Polish government by Princes Czartoryski Foundation, represented by Adam Karol Czartoryski, the last direct descendant of Izabela Czartoryska Flemming and Adam George Czartoryski, who brought the painting to Poland from Italy in 1798.

La Belle Ferronnière (French pronunciation: [la bɛl fɛʁɔnjɛʁ]) is a portrait painting of a lady, by Leonardo da Vinci, in the Louvre. It is also known as Portrait of an Unknown Woman. The painting's title, applied as early as the seventeenth century, identifying the sitter as the wife or daughter of an ironmonger (a ferronnier), was said to be discreetly alluding to a reputed mistress of Francis I of France, married to a certain Le Ferron. Later she was tentatively identified as Lucretia Crivelli, a married lady-in-waiting to Duchess Beatrice of Milan, who became another of the Duke's mistresses.

Leonardo's Lady with an Ermine has also been known by this name. This was once believed to be a portrait of Cecilia Gallerani, one of the mistresses of Ludovico Sforza, Duke of Milan. The narrative and the title were applied to Lady with an Ermine when it was in Princess Izabela Czartoryska's collection, and became confused with La Belle Ferronnière by the presence of a ferronnière, a type of accessory worn across the forehead, in the painting as well.

Gian Galeazzo Sforza (20 June 1469 – 21 October 1494), also known as Giovan Galeazzo Sforza, was the sixth Duke of Milan. He was the father of Bona Maria Sforza, who later became Queen of Poland. He died in 1494 aged 25 and was succeeded by his uncle, Ludovico Sforza.

A Treatise on Painting (Trattato della pittura) is a collection of Leonardo da Vinci's writings entered in his notebooks under the general heading "On Painting". The manuscripts were begun in Milan while Leonardo was under the service of Ludovico Sforza and gathered together by his heir Francesco Melzi. An abridged version of the treatise was first published in France in 1651. After Melzi's manuscript was rediscovered in the Vatican Library, the treatise was published in its modern form in 1817.