Lorenzo de' Medici, Duke of Urbino in the context of "Flattery"

Pope Leo X (Italian: Leone X; born Giovanni di Lorenzo de' Medici, 11 December 1475 – 1 December 1521) was head of the Catholic Church and ruler of the Papal States from 9 March 1513 to his death in December 1521.

Born into the prominent political and banking Medici family of Florence, Giovanni was the second son of Lorenzo de' Medici, ruler of the Florentine Republic, and was elevated to the cardinalate in 1489. Following the death of Pope Julius II, Giovanni was elected pope after securing the backing of the younger members of the College of Cardinals. Early on in his rule he oversaw the closing sessions of the Fifth Council of the Lateran, but struggled to implement the reforms agreed. In 1517 he led a costly war that succeeded in securing his nephew Lorenzo di Piero de' Medici as Duke of Urbino, but reduced papal finances.

Catherine de' Medici (Italian: Caterina de' Medici, pronounced [kateˈriːna de ˈmɛːditʃi]; French: Catherine de Médicis, pronounced [katʁin də medisis]; 13 April 1519 – 5 January 1589) was an Italian Florentine noblewoman of the Medici family and Queen of France from 1547 to 1559 by marriage to King Henry II. She was the mother of French kings Francis II, Charles IX, and Henry III, and a cousin to Pope Clement VII. The years during which her sons reigned have been called "the age of Catherine de' Medici" since she had extensive, albeit at times varying, influence on the political life of France.

Catherine was born in Florence to Lorenzo de' Medici, Duke of Urbino, and his wife, Madeleine de La Tour d'Auvergne. In 1533, at the age of 14, Catherine married Henry, the second son of King Francis I and Queen Claude of France, who would become Dauphin of France (heir to the throne) upon the death of his elder brother Francis in 1536. Catherine's marriage was arranged by Clement VII. Henry largely excluded Catherine from state affairs during his reign, instead showering favours on his chief mistress, Diane de Poitiers, who wielded significant influence in the court. Henry's sudden accidental death in 1559 thrust Catherine into the political arena as mother of the frail 15-year-old Francis II. When Francis II died the next year, she became regent on behalf of her 10-year-old son Charles IX and thus gained sweeping powers. After Charles died in 1574, Catherine played a key role in the reign of her third son, Henry III. He dispensed with her advice only in the last months of her life but outlived her by just seven months.

Francesco Maria I della Rovere (25 March 1490 – 20 October 1538) was an Italian condottiero, who was Duke of Urbino from 1508 to 1516 and, after retaking the throne from Lorenzo II de' Medici, from 1521 to 1538.