Lodi, California in the context of "San Joaquin County, California"

Central California is generally thought of as the middle third of the U.S. state of California, north of Southern California (which includes Los Angeles and San Diego) and south of Northern California (which includes San Francisco and San Jose). It includes the northern portion of the San Joaquin Valley (which itself is the southern portion of the Central Valley, beginning at the Sacramento–San Joaquin River Delta), part of the Central Coast, the central hills of the California Coast Ranges and the foothills and mountain areas of the central Sierra Nevada.

Central California is considered to be west of the crest of the Sierra Nevada. East of the Sierra is Eastern California. The largest cities in the region (over 50,000 population), from most to least populous, are Sacramento, Fresno, Bakersfield, Stockton, Modesto, Elk Grove, Salinas, Visalia, Clovis, Tracy, Merced, Manteca, Turlock, Tulare, Madera, Lodi, Porterville, Santa Cruz, Hanford, and Delano. Over time, droughts and wildfires have increased in frequency and become less seasonal and more year-round, further straining the region's water security.

Interstate 580 (I-580) is an approximately 76-mile-long (122 km) east–west auxiliary Interstate Highway in Northern California. The heavily traveled spur route of I-80 runs from US Route 101 (US 101) in San Rafael in the San Francisco Bay Area to I-5 at a point outside the southern city limits of Tracy in the Central Valley. I-580 forms a concurrency with I-80 between Albany and Oakland, the latter of which is the location of the MacArthur Maze interchange immediately east of the San Francisco–Oakland Bay Bridge. I-580 provides a connection from the Bay Area to the southern San Joaquin Valley and Southern California via I-5, as I-5 bypasses the Bay Area to the east.

A portion of I-580 is called the MacArthur Freeway, after General Douglas MacArthur. Other portions are named the John T. Knox Freeway (after a former speaker pro tempore of the California State Assembly), the Eastshore Freeway (after its location on San Francisco Bay), the Arthur H. Breed Jr. Freeway (after a former California State assemblyperson and senator—the stretch itself lying between the cities of Castro Valley and Dublin), the William Elton "Brownie" Brown Freeway (after a Tracy resident instrumental in determining the route of I-5 through the San Joaquin Valley), the Sgt. Daniel Sakai Memorial Highway (after the Castro Valley resident and Oakland SWAT officer killed in the 2009 shootings of Oakland police officers), and the John P. Miller Memorial Highway (after the Lodi resident and California Highway Patrol officer killed while chasing down a DUI driver).