List of largest stars in the context of VY Canis Majoris

Red supergiants (RSGs) are stars with a supergiant luminosity class (Yerkes class I) and a stellar classification K or M. They are the largest stars in the universe in terms of volume, although they are not the most massive or luminous. Betelgeuse and Antares A are the brightest and best known red supergiants (RSGs), indeed the only first magnitude red supergiant stars.

Cepheus is a constellation in the deep northern sky, named after Cepheus, a king of Aethiopia in Greek mythology. It is one of the 48 constellations listed by the second century astronomer Ptolemy, and it remains one of the 88 constellations in the modern times.

The constellation's brightest star is Alderamin (Alpha Cephei), with an apparent magnitude of 2.5. Delta Cephei is the prototype of an important class of star known as a Cepheid variable. RW Cephei, an orange hypergiant, together with the red supergiants Mu Cephei, MY Cephei, VV Cephei, V381 Cephei, and V354 Cephei are among the largest stars known. In addition, Cepheus also has the hyperluminous quasar S5 0014+81, which hosts an ultramassive black hole in its core, reported at 40 billion solar masses, about 10,000 times more massive than the central black hole of the Milky Way, making this among the most massive black holes currently known.

A hypergiant (luminosity class 0, Ia-0 or Ia) is a very rare type of star that has an extremely high luminosity, mass, size and mass loss because of its extreme stellar winds. The term hypergiant is defined as luminosity class 0 (zero) in the MKK system. However, this is rarely seen in literature or in published spectral classifications, except for specific well-defined groups such as the yellow hypergiants, RSG (red supergiants), or blue B(e) supergiants with emission spectra. More commonly, hypergiants are classed as Ia-0 or Ia, but red supergiants are rarely assigned these spectral classifications. Astronomers are interested in these stars because they relate to understanding stellar evolution, especially star formation, stability, and their expected demise as supernovae. Notable examples of hypergiants include the Pistol Star, a blue hypergiant located close to the Galactic Center and one of the most luminous stars known; Rho Cassiopeiae, a yellow hypergiant that is one of the brightest to the naked eye; and Mu Cephei (Herschel's "Garnet Star"), one of the largest and brightest stars known.

Cygnus is a northern constellation on the plane of the Milky Way, deriving its name from the Latinized Greek word for "swan". Cygnus is one of the most recognizable constellations of the northern summer and autumn, and it features a prominent asterism known as the Northern Cross (in contrast to the Southern Cross). Cygnus was among the 48 constellations listed by the 2nd century astronomer Ptolemy, and it remains one of the 88 modern constellations.

Cygnus contains Deneb (ذنب, translit. ḏanab, tail)—one of the brightest stars in the night sky and the most distant first-magnitude star—as its "tail star" and one corner of the Summer Triangle the constellation forming an east pointing altitude of the triangle. It also has some notable X-ray sources and the giant stellar association of Cygnus OB2. One of the stars of this association, NML Cygni, is one of the largest stars currently known. The constellation is also home to Cygnus X-1, a distant X-ray binary containing a supergiant and unseen massive companion that was the first object widely held to be a black hole.Many star systems in Cygnus have known planets as a result of the Kepler Mission observing one patch of the sky, an area around Cygnus.

Antares is the brightest star in the constellation of Scorpius. It has the Bayer designation α Scorpii, which is Latinised to Alpha Scorpii. Often referred to as "the heart of the scorpion", Antares is flanked by σ Scorpii and τ Scorpii near the center of the constellation. Distinctly reddish when viewed with the naked eye, Antares is a slow irregular variable star that ranges in brightness from an apparent visual magnitude of +0.6 down to +1.6. It is on average the fifteenth-brightest star in the night sky. Antares is the brightest and most evolved stellar member of the Scorpius–Centaurus association, the nearest OB association to the Sun. It is located about 170 parsecs (550 ly) from Earth at the rim of the Upper Scorpius subgroup, and is illuminating the Rho Ophiuchi cloud complex in its foreground.

Classified as spectral type M1.5Iab-Ib, Antares is a red supergiant, a large evolved massive star and one of the largest stars visible to the naked eye. If placed at the center of the Solar System, it would extend out to somewhere in the asteroid belt. Its mass is calculated to be 13 or 15 to 16 times that of the Sun. Antares appears as a single star when viewed with the naked eye, but it is actually a binary star system, with its two components called α Scorpii A and α Scorpii B. The brighter of the pair is the red supergiant, while the fainter is a hot main sequence star of magnitude 5.5. They have a projected separation of about 79.1 Tm (529 AU).