Lodhran District (Saraiki: ضِلع لودهراں), is a district in the province of Punjab, Pakistan, with the city of Lodhran as its capital. Located on the northern side of the River Sutlej, it is bounded to the north by the districts of Multan, Khanewal and Vehari, to the south by Bahawalpur, to the east lie the districts of Vehari and Bahawalpur; while district Multan lies on the western side.
Lodhran was split off as a separate district from Multan in 1991. It has the lowest Human Development Index of all districts in Punjab, and is among the thirty poorest districts in Pakistan. It is a well-known cotton-growing area.