Linear accelerator in the context of "SLAC National Accelerator Laboratory"

SLAC National Accelerator Laboratory, originally named the Stanford Linear Accelerator Center, is a federally funded research and development center in Menlo Park, California, United States. Founded in 1962, the laboratory is now sponsored by the United States Department of Energy and administrated by Stanford University. It is the site of the Stanford Linear Accelerator, a 3.2 km (2 mi) linear accelerator constructed in 1966 that could accelerate electrons to energies of 50 GeV.

Today SLAC research centers on a broad program in atomic and solid-state physics, chemistry, biology, and medicine using X-rays from synchrotron radiation and a free-electron laser as well as experimental and theoretical research in elementary particle physics, accelerator physics, astroparticle physics, and cosmology. The laboratory is under the programmatic direction of the United States Department of Energy Office of Science.

In accelerator physics, a beamline refers to the trajectory of the beam of particles, including the overall construction of the path segment (guide tubes, diagnostic devices) along a specific path of an accelerator facility. This part is either

• the line in a linear accelerator along which a beam of particles travels, or
• the path leading from particle generator (e.g. a cyclic accelerator, synchrotron light sources, cyclotrons, or spallation sources) to the experimental end-station.

Beamlines usually end in experimental stations that utilize particle beams or synchrotron light obtained from a synchrotron, or neutrons from a spallation source or research reactor. Beamlines are used in experiments in particle physics, materials science, life science, chemistry, and molecular biology, but can also be used for irradiation tests or to produce isotopes.

Megavoltage X-rays are produced by linear accelerators ("linacs") operating at voltages in excess of 1000 kV (1 MV) range, and therefore have an energy in the MeV range. The voltage in this case refers to the voltage used to accelerate electrons in the linear accelerator and indicates the maximum possible energy of the photons which are subsequently produced. They are used in medicine in external beam radiotherapy to treat neoplasms, cancer and tumors. Beams with a voltage range of 4-25 MV are used to treat deeply buried cancers because radiation oncologists find that they penetrate well to deep sites within the body. Lower energy x-rays, called orthovoltage X-rays, are used to treat cancers closer to the surface.

Megavoltage x-rays are preferred for the treatment of deep lying tumours as they are attenuated less than lower energy photons, and will penetrate further, with a lower skin dose. Megavoltage X-rays also have lower relative biological effectiveness than orthovoltage x-rays. These properties help to make megavoltage x-rays the most common beam energies typically used for radiotherapy in modern techniques such as IMRT.