Leukemia in the context of "Glucocorticoid"

On 11 March 2011, a major nuclear accident started at the Fukushima Daiichi Nuclear Power Plant in Ōkuma, Fukushima, Japan. The direct cause was the Tōhoku earthquake and tsunami, which resulted in electrical grid failure and damaged nearly all of the power plant's backup energy sources. The subsequent inability to sufficiently cool reactors after shutdown compromised containment and resulted in the release of radioactive contaminants into the surrounding environment. The accident was rated seven (the maximum severity) on the International Nuclear Event Scale by Nuclear and Industrial Safety Agency, following a report by the JNES (Japan Nuclear Energy Safety Organization). It is regarded as the worst nuclear incident since the Chernobyl disaster in 1986, which was also rated a seven on the International Nuclear Event Scale.

According to the United Nations Scientific Committee on the Effects of Atomic Radiation, "no adverse health effects among Fukushima residents have been documented that are directly attributable to radiation exposure from the Fukushima Daiichi nuclear plant accident". Insurance compensation was paid for one death from lung cancer, but this does not prove a causal relationship between radiation and the cancer. Six other persons have been reported as having developed cancer or leukemia. Two workers were hospitalized because of radiation burns, and several other people sustained physical injuries as a consequence of the accident.

Hematopathology or hemopathology (both also spelled haem-, see spelling differences) is the study of diseases and disorders affecting and found in blood cells, their production, and any organs and tissues involved in hematopoiesis, such as bone marrow, the spleen, and the thymus. Diagnoses and treatment of diseases such as leukemia and lymphoma often deal with hematopathology; techniques and technologies include flow cytometry studies and immunohistochemistry.

In the United States, hematopathology is a board-certified subspecialty by the American Board of Pathology. Board-eligible or board-certified hematopathologists are usually pathology residents (anatomic, clinical, or combined) who have completed hematopathology fellowship training after their pathology residency. The hematopathology fellowship lasts either one or two years. A physician who practices hematopathology is called a hematopathologist.

Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure (whether it is acute or chronic), route of exposure, species, age, sex, and environment. Toxicologists are experts on poisons and poisoning. There is a movement for evidence-based toxicology as part of the larger movement towards evidence-based practices. Toxicology is currently contributing to the field of cancer research, since some toxins can be used as drugs for killing tumor cells. One prime example of this is ribosome-inactivating proteins, tested in the treatment of leukemia.

The word toxicology (/ˌtɒksɪˈkɒlədʒi/) is a neoclassical compound from Neo-Latin, first attested c. 1799, from the combining forms toxico- + -logy, which in turn come from the Ancient Greek words τοξικός toxikos, "poisonous", and λόγος logos, "subject matter").

Jerzy Marian Grotowski (Polish: [ˈjɛʐɨ ˈmarjan grɔˈtɔfskʲi]; 11 August 1933 – 14 January 1999) was a Polish theatre director and dramatic theorist whose innovative approaches to acting, training and theatrical production have significantly influenced theatre today. He is considered one of the most influential theatre practitioners of the 20th century as well as one of the founders of experimental theatre.

He was born in Rzeszów, in southeastern Poland, in 1933 and studied acting and directing at the Ludwik Solski Academy of Dramatic Arts in Kraków and Russian Academy of Theatre Arts in Moscow. He debuted as a director in 1957 in Kraków with Eugène Ionesco's play Chairs (co-directed with Aleksandra Mianowska) and shortly afterward founded a small laboratory theatre in 1959 in the town of Opole in Poland. During the 1960s, the company began to tour internationally and his work attracted increasing interest. As his work gained wider acclaim and recognition, Grotowski was invited to work in the United States and left Poland in 1982. Although the company he founded in Poland closed a few years later in 1984, he continued to teach and direct productions in Europe and America. However, Grotowski became increasingly uncomfortable with the adoption and adaptation of his ideas and practices, particularly in the US. So, at what seemed to be the height of his public profile, he left America and moved to Italy where he established the Grotowski Workcenter in 1985 in Pontedera, near Pisa. At this centre, he continued his theatre experimentation and practice, and it was here that he continued to direct training and private theatrical events almost in secret for the last twenty years of his life. Suffering from leukemia and a heart condition, he died in 1999 at his home in Pontedera.

Exposure to ionizing radiation is known to increase the future incidence of cancer, particularly leukemia. The mechanism by which this occurs is well understood, but quantitative models predicting the level of risk remain controversial. The most widely accepted model posits that the incidence of cancers due to ionizing radiation increases linearly with effective radiation dose at a rate of 5.5% per sievert; if correct, natural background radiation is the most hazardous source of radiation to general public health, followed by medical imaging as a close second. Additionally, the vast majority of non-invasive cancers are non-melanoma skin cancers caused by ultraviolet radiation (which lies on the boundary between ionizing and non-ionizing radiation). Non-ionizing radio frequency radiation from mobile phones, electric power transmission, and other similar sources have been investigated as a possible carcinogen by the WHO's International Agency for Research on Cancer, but to date, no evidence of this has been observed.

Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells. HSCT may be autologous (the patient's own stem cells are used), syngeneic (stem cells from an identical twin), or allogeneic (stem cells from a donor).

It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma, leukemia, some types of lymphoma and immune deficiencies. In these cases, the recipient's immune system is usually suppressed with radiation or chemotherapy before the transplantation. Infection and graft-versus-host disease are major complications of allogeneic HSCT.

2,6-diaminopurine (2,6-DAP, also known as 2-aminoadenine, standard IUPAC symbol nA) is a compound once used in the treatment of leukemia. It is found instead of adenine (A) in the genetic material of some bacteriophage viruses,

In August 2011, a report, based on NASA studies with meteorites found on Earth, was published suggesting 2,6-diaminopurine and related organic molecules, including the DNA and RNA components adenine and guanine, may have been formed extraterrestrially in outer space.

Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original diagnosis of leukemia. In most cases, these can be classified according to the lineage, myeloid or lymphoid, of the malignant cells that grow uncontrolled, but some are mixed and for those such an assignment is not possible.