The Treaty for the Prohibition of Nuclear Weapons in Latin America and the Caribbean (commonly known as the Treaty of Tlatelolco) is an international treaty that establishes the nuclear disarmament of Latin America and the Caribbean. It was proposed by Adolfo López Mateos, the President of Mexico, and promoted by the Mexican diplomats Alfonso García Robles, Ismael Moreno Pino and Jorge Castañeda as a response to the Cuban Missile Crisis (1962). For his efforts in favour of the reduction of nuclear weapons, García Robles was awarded the Nobel Peace Prize in 1982.
The following year, López Mateos invited President of Bolivia Víctor Paz Estenssoro, President of Brazil João Goulart, President of Chile Jore Alessandri, and President of Ecuador Carlos Julio Arosemena Monroy to make a public statement following the Crisis. They issued a Joint Declaration on 29 April 1963, announcing their intent to undertake a multilateral Latin American nuclear agreement. The presentation of the Joint Declaration at the United Nations General Assembly (UNGA) authorised Mexico to lead the treaty's drafting. The 18th session of the UNGA approved the Preliminary Meeting on the Denuclearization of Latin America (REUPRAL), held from 23 to 27 November 1964. During the first session, REUPRAL established the Preparatory Commission for the Denuclearization of Latin America (COPREDAL).