Larkana District (Sindhi: لاڙڪاڻو ضلعو; Urdu: ضلع لاڑکانہ) is a district of the Sindh province of Pakistan. Its largest city is Larkana, which sits on the banks of the Indus River.
Other towns in the district include Ratodero, Dokri, Bakrani, and Naodero. In 2005, the Government of Pakistan under Pervez Musharraf bifurcated the district, forming a new district called Qamber and Shahdadkot, with the two towns of Qambar Khan and Shahdadkot.