The Sangro is a river in eastern central Italy, known in ancient times as Sagrus from the Greek Sagros or Isagros, Ισαγρος.
It rises in the middle of Abruzzo National Park near Pescasseroli in the Apennine Mountains. It flows southeast past Pescasseroli, Opi and Villetta Barrea and flows into the artificial lake Lago di Barrea. Likewise, it then flows northeast through Alfedena, Castel di Sangro, Ateleta, Quadri, and Villa Santa Maria, before flowing into the Lago di Bomba. From there it flows northeast, where it is joined by the Aventino, then into the Adriatic Sea south of Punta Cavalluccio.