The Kushano-Sasanian Kingdom or the Indo-Sasanian Kingdom was a polity established by the Sasanian Empire in Bactria during the 3rd and 4th centuries. The Sasanian Empire captured the provinces of Sogdia, Bactria and Gandhara from the declining Kushan Empire following a series of wars in 225 CE. The local Sasanian governors then went on to take the title of Kushanshah (KΟÞANΟ ÞAΟ or Koshano Shao in the Bactrian language) or "King of the Kushans", and to mint coins. They are sometimes considered as forming a "sub-kingdom" inside the Sasanian Empire.
This administration continued until 360–370, when the Kushano-Sasanians lost much of their domains to the invading Kidarites; the remainder was incorporated into the Sasanian Empire proper. Later, the Kidarites were in turn displaced by the Hephthalites.