Kujula Kadphises in the context of "Kushanas"

The Kushan Empire (c. 30–c. 375 CE) was a syncretic empire formed by the Yuezhi in the Bactrian territories in the early 1st century. It spread to encompass much of what is now Afghanistan, Eastern Iran, India, Pakistan, Western Nepal, Tajikistan and Uzbekistan. Kushan territory in India went at least as far as Saketa and Sarnath, now near Varanasi in Uttar Pradesh, where inscriptions have been found dating to the era of the Kushan emperor Kanishka the Great.

The Kushans were most probably one of five branches of the Yuezhi confederation, an Indo-European nomadic people of possible Tocharian origin, who migrated from northwestern China (Xinjiang and Gansu) and settled in ancient Bactria. The founder of the dynasty, Kujula Kadphises, followed Iranian and Greek cultural ideas and iconography after the Greco-Bactrian tradition and was a follower of the Shaivite sect of Hinduism. Many of the later Kushan kings after Kujula, were also patrons of Hinduism, including (but not limited to) Vima Kadphises and Vasudeva II. The Kushans in general were also great patrons of Buddhism, and, starting with Emperor Kanishka, they employed elements of Zoroastrianism in their pantheon. They played an important role in the spread of Buddhism to Central Asia and China, ushering in a period of relative peace for 200 years, sometimes described as "Pax Kushana".

Kanishka I, also known as Kanishka the Great, was an emperor of the Kushan dynasty, under whose reign (c. 127–150 CE) the empire reached its zenith. He is famous for his military, political, and spiritual achievements. A descendant of Kujula Kadphises, founder of the Kushan empire, Kanishka came to rule an empire extending from Central Asia and Gandhara to Pataliputra on the Gangetic plain. The main capital of his empire was located at Puruṣapura (Peshawar) in Gandhara, with another major capital at Mathura. Coins of Kanishka were found in Tripuri (present-day Jabalpur).

Although he never converted to the religion, his conquests and patronage of Buddhism played an important role in the development of the Silk Road, and in the transmission of Mahayana Buddhism from Gandhara across the Karakoram range to China. Around 127 CE, he replaced Greek with Bactrian as the official language of administration in the empire.

The Indo-Scythian Kingdom, also known as Indo-Sakas, were a group of nomadic people of Iranic Scythian origin who migrated from Central Asia southward into the Indus Valley region of present-day Pakistan and also regions of Afghanistan, Eastern Iran and northern India. The migrations persisted from the middle of the second century BCE to the fourth century CE.

The first Saka king in the subcontinent was Maues/Moga (first century BCE) who established Saka power in Gandhara, the Indus Valley, and other regions. The Indo-Scythians extended their supremacy over the north-western subcontinent, conquering the Indo-Greeks and other local peoples. They were apparently subjugated by the Kushan Empire's Kujula Kadphises or Kanishka. The Saka continued to govern as satrapies, forming the Northern Satraps and Western Satraps. The power of the Saka rulers began to decline during the 2nd century CE after the Indo-Scythians were defeated by the Satavahana emperor Gautamiputra Satakarni. Indo-Scythian rule in the northwestern subcontinent ended when the last Western Satrap, Rudrasimha III, was defeated by the Gupta emperor Chandragupta II in 395 CE.

The Indo-Scythians or Indo-Sakas were the branch of Saka empire in South Asia. Indo-Scythians were a group of nomadic Iranian peoples of Scythian origin who migrated from Central Asia southward into the northwestern Indian subcontinent. They started expansion in South Asia from 200 to 100 BCE and established rule between 100 and 80 BCE, their rule in Indian subcontinent was lasted until 415s CE.

The first Saka king of India was Maues/Moga (1st century BCE) who established Saka power in Gandhara. The Indo-Scythians extended their supremacy over north-western subcontinent, conquering the Indo-Greeks and other local kingdoms. The Indo-Scythians were apparently subjugated by the Kushan Empire, by either Kujula Kadphises or Kanishka. Yet the Saka continued to govern as satrapies, forming the Northern Satraps and Western Satraps. The power of the Saka rulers started to decline in the 2nd century CE after the Indo-Scythians were defeated by the Satavahana emperor Gautamiputra Satakarni. Indo-Scythian rule in the northwestern subcontinent ceased when the last Western Satrap Rudrasimha IIII was defeated by the Gupta emperor Chandragupta II in 395 CE. Later Western Saka rulers (c. 396 to 415 CE) were conquered by Imperial Gupta Empire and it brings to end of Saka rule in Indian subcontinent.