Khoshut Khanate in the context of "Khoshut"

While the Tibetan Plateau has been inhabited since pre-historic times, most of Tibet's history went unrecorded until the creation of Tibetan script in the 7th century. Tibetan texts refer to the kingdom of Zhangzhung (c. 500 BCE – 625 CE) as the precursor of later Tibetan kingdoms and the originators of the Bon religion. While mythical accounts of early rulers of the Yarlung dynasty exist, historical accounts begin with the introduction of Tibetan script from the unified Tibetan Empire in the 7th century. Following the dissolution of Tibetan Empire and a period of fragmentation in the 9th–10th centuries, a Buddhist revival in the 10th–12th centuries saw the development of three of the four major schools of Tibetan Buddhism.

After a period of control by the Mongol Empire and the also Mongol led Yuan dynasty, Tibet effectively became independent in the 14th century and was ruled by a succession of noble houses for the next 300 years. In the 16th century, the Dalai Lama title was created by Altan Khan, and as requested by the family of Altan Khan, seal of authority was granted to the Dalai Lama by the Wanli Emperor. In the 17th century, the senior lama of the Gelug school, the Dalai Lama, became the head of state with the aid of the Khoshut Khanate. Seal of authority and golden sheets were granted by the Shunzhi Emperor to both the Dalai Lama and the founder Güshi Khan of Khoshut Khanate in 1653. In 1717, the Dzungar Khanate invaded Lhasa, killed Lha-bzang Khan of the Khoshut Khanate, which effectively destroyed the Khoshut Khanate. The Qing dynasty then sent military troops in the same year to fight the Dzungars, but failed.

Güshi Khan (1582 – 14 January 1655) was a Khoshut prince and founder of the Khoshut Khanate, who supplanted the Tumed descendants of Altan Khan as the main benefactor of the Dalai Lama and the Gelug school of Tibetan Buddhism. In 1637, Güshi Khan defeated a rival Mongol prince Choghtu Khong Tayiji, a Kagyu follower, near Qinghai Lake and established his khanate in Tibet over the next years. His military assistance to the Gelug school enabled the 5th Dalai Lama to establish political control over Tibet.

Lha-bzang Khan (Mongolian: ᠯᠠᠽᠠᠩ ᠬᠠᠭᠠᠨ Lazang Khaan; Tibetan: ལྷ་བཟང༌, ZWPY: Lhasang; alternatively, Lhazang or Lapsangn or Lajang; d.1717) was the ruler of the Khoshut (also spelled Qoshot, Qośot, or Qosot) tribe of the Oirats. He was the son of Tenzin Dalai Khan (1668–1701) and grandson (or great-grandson) of Güshi Khan, being the last khan of the Khoshut Khanate and Oirat King of Tibet. He acquired effective power as ruler of Tibet by eliminating the regent (desi) Sangye Gyatso and the Sixth Dalai Lama, Tsangyang Gyatso, but his rule was cut short by an invasion by another group of Oirats, the Dzungar people. At length, this led to the direct involvement of the Chinese Qing dynasty in the Tibetan politics.

There were several Mongol invasions of Tibet. The earliest is the alleged plot to invade Tibet by Genghis Khan in 1206, which is considered anachronistic; there is no evidence of Mongol-Tibetan encounters prior to the military campaign in 1240. The first confirmed campaign is the invasion of Tibet by the Mongol general Doorda Darkhan in 1240, a campaign of 30,000 troops that resulted in 500 casualties. The campaign was smaller than the full-scale invasions used by the Mongols against large empires. The purpose of this attack is unclear, and is still in debate among Tibetologists. Then in the late 1240s Mongol prince Godan invited Sakya lama Sakya Pandita, who urged other leading Tibetan figures to submit to Mongol authority. This is generally considered to have marked the beginning of Mongol rule over Tibet, as well as the establishment of patron and priest relationship between Mongols and Tibetans. These relations were continued by Kublai Khan, who founded the Mongol Yuan dynasty and granted authority over whole Tibet to Drogon Chogyal Phagpa, nephew of Sakya Pandita. The Sakya-Mongol administrative system and Yuan administrative rule over the region lasted until the mid-14th century, when the Yuan dynasty began to crumble.

In the early 17th century, the Oirat Mongols again conquered the region and established the Khoshut Khanate. Since then the Mongols had intervened in Tibetan politics until the Qing conquest of Mongolia and Dzungaria.

The Ganden Phodrang or Ganden Podrang (Tibetan: དགའ་ལྡན་ཕོ་བྲང, Wylie: dGa' ldan pho brang, Lhasa dialect: [ˈkɑ̃̀tɛ̃̀ ˈpʰóʈɑ̀ŋ]; Chinese: 甘丹頗章; pinyin: Gāndān Pōzhāng) was the Tibetan system of government established by the 5th Dalai Lama in 1642, when the Oirat lord Güshi Khan who founded the Khoshut Khanate conferred all spiritual and political power in Tibet to him in a ceremony in Shigatse. During the ceremony, the Dalai Lama "made a proclamation declaring that Lhasa would be the capital of Tibet and the government of would be known as Gaden Phodrang" which eventually became the seat of the Gelug school's leadership authority. The Dalai Lama chose the name of his monastic residence at Drepung Monastery for the new Tibetan government's name: Ganden (དགའ་ལྡན), the Tibetan name for Tushita heaven, which, according to Buddhist cosmology, is where the future Buddha Maitreya resides; and Phodrang (ཕོ་བྲང), a palace, hall, or dwelling. Lhasa's Red Fort again became the capitol building of Tibet, and the Ganden Phodrang operated there and adjacent to the Potala Palace until 1959.

During the 17th century, the Dalai Lama established the priest and patron relationship with China's Qing emperors, a few decades before the Chinese expedition to Tibet (1720). Meanwhile, the Qing became increasingly active in governing Tibet with the establishment of imperial resident (Amban) and Chinese garrison stationed in Lhasa since the early 18th century and took advantage of crisis situations in Tibet to intervene in Tibetan affairs each time, although this also caused some dissatisfaction and uprisings within Tibet, such as the Batang uprising in 1905. A governing council known as the Kashag also operated in the Ganden Phodrang administration. During the British expedition to Tibet (1904) and the Chinese expedition to Tibet (1910) before the 1911 Revolution which led to the fall of the Qing dynasty in 1912, the Ganden Phodrang continued to govern Tibet under the Qing protectorate. After the Chinese Civil War which led to the establishment of the People's Republic of China and the subsequent signing of the Sino-Tibetan Seventeen Point Agreement in 1951, the annexation of Tibet by the People's Republic of China began, although the Dalai Lama escaped from Tibet and declared the revocation of the agreement following the 1959 Tibetan uprising.

The 6th Dalai Lama, Tsangyang Gyatso (Tibetan: ཚངས་དབྱངས་རྒྱ་མཚོ, Wylie: tshangs-dbyangs rgya-mtsho, ZWPY: Cangyang Gyamco; 1 March 1683 – after 1706), was recognized as the 6th Dalai Lama after a delay of many years, permitting the Potala Palace to be completed. He was an unconventional Dalai Lama that preferred a Nyingma school yogi's life to that of an ordained monk. He was later kidnapped and deposed by the Koshut Lha-bzang Khan.

The death of the 5th Dalai Lama remained concealed for many years by his Kalon, in order to complete the building of the Potala Palace. The 6th Dalai Lama was born in southern Tibet, known as "Monyul", at Urgelling Monastery, which is in modern-day Tawang district, Arunachal Pradesh, India. He was officially located at the age of either 13 or 14.

Yeshe Gyatso (Wylie: Ye shes rgya mtsho) (1686–1725) was a pretender for the position of the 6th Dalai Lama of Tibet. Declared by Lha-bzang Khan of the Khoshut Khanate on June 28, 1707, he was the only unofficial Dalai Lama. While praised for his personal moral qualities, he was not recognized by the bulk of the Tibetans and Mongols and is not counted in the official list of the Dalai Lamas.