Kappa-opioid receptor in the context of "Hallucinogen"

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⭐ Core Definition: Kappa-opioid receptor

The Îș-opioid receptor or kappa opioid receptor, abbreviated KOR or KOP for its ligand ketazocine, is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene. The KOR is coupled to the G protein Gi/G0 and is among related receptors that bind opioid-like compounds in the brain and are responsible for mediating the effects of these compounds. These include altering nociception, mood, reward system, and motor control.

KOR is one of the two opioid receptors that bind dynorphin opioid peptides as the primary endogenous ligands, the other being newly deorphanized GPR139 receptor. In addition, oxytocin was found to be a positive allosteric modulator of KOR, and a variety of natural alkaloids, terpenes and synthetic ligands bind to the receptor.

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👉 Kappa-opioid receptor in the context of Hallucinogen

Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Hallucinogens are often categorized as either being psychedelics, dissociatives, or deliriants, but not all hallucinogens fall into these three classes.

Examples of hallucinogens include psychedelics or serotonin 5-HT2A receptor agonists like LSD, psilocybin, mescaline, and DMT; dissociatives or NMDA receptor antagonists like ketamine, PCP, DXM, and nitrous oxide; deliriants or antimuscarinics like scopolamine and diphenhydramine; cannabinoids or cannabinoid CB1 receptor agonists like THC, nabilone, and JWH-018; Îș-opioid receptor agonists like salvinorin A and pentazocine; GABAA receptor agonists like muscimol and gaboxadol; oneirogens like ibogaine and harmaline; and others like nutmeg, carbogen, glaucine, and hallucinogenic bolete mushrooms.

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In this Dossier
LINKED FROM (PARENTS)
← Hallucinogen
LINKS TO (CHILDREN)
Ligand (biochemistry) → Ketazocine → G protein-coupled receptor → Gene → G protein → Gi alpha subunit → Receptor (biochemistry) → Opioid → Brain → Nociception → Mood (psychology) → Reward system → Motor control → Opioid receptor → Dynorphin → Opioid peptide → Endogeny (biology) → GPR139 → Oxytocin → Positive allosteric modulator → Alkaloid → Terpene → Synthetic substance →