Justin I in the context of "Anastasius I Dicorus"

The Byzantine Empire under the Justinian dynasty began in 518 AD with the accession of Justin I. Under the Justinian dynasty, particularly the reign of Justinian I, the empire reached its greatest territorial extent since the fall of its Western counterpart, reincorporating North Africa, southern Illyria, southern Spain, and Italy into the empire. The Justinian dynasty ended in 602 with the deposition of Maurice and the accession of his successor, Phocas.

Scupi (Ancient Greek: Σκούποι, romanized: Skoúpoi; Macedonian: Скупи) is an archaeological site located between Zajčev Rid (Зајчев Рид 'Rabbit Hill') and the Vardar River, several kilometers from the center of modern Skopje in North Macedonia. A Roman military camp was founded here in the second century BC on the site of an older Dardanian settlement. It became later Colonia Flavia Aelia Scupi and many veteran legionnaires were settled there. A Roman town was founded in the time of Domitian (AD 81–96) and Scupi became the chief center for romanizing Dardania. It was abandoned in AD 518 during interregnum between Anastasius I Dicorus and Justin I after an earthquake destroyed the city.

Niš (/ˈniːʃ/; Serbian Cyrillic: Ниш, Serbian pronunciation: [nîːʃ] ; names in other languages), less often spelled in English as Nish, is the third largest city in Serbia and the administrative center of the Nišava District. It is located in the southern part of Serbia. According to the 2022 census, the city proper has a population of 178,976, while its administrative area has a population of 249,501 inhabitants.

Several Roman emperors were born in Niš or used it as a residence: Constantine the Great, the first Christian emperor and the founder of Constantinople, Constantius III, Constans, Vetranio, Julian, Valentinian I, Valens; and Justin I. Emperor Claudius Gothicus decisively defeated the Goths at the Battle of Naissus (present-day Niš). Later playing a prominent role in the history of the Byzantine Empire, the city's past would earn it the nickname Imperial City.

The Gepids (Latin: Gepidae, Gipedae; Ancient Greek: Γήπαιδες, romanized: Gḗpaides) were an East Germanic tribe who lived in the area of modern Romania, Hungary, and Serbia, roughly between the Tisza, Sava, and Carpathian Mountains. They were said to share the religion and language of the Goths and Vandals.

They are first mentioned by Roman sources in the third century. In the fourth century, they were among the peoples incorporated into the Hunnic Empire, within which they formed an important part. After the death of Attila, the Gepids under their leader Ardaric, led an alliance of other peoples who had been in the empire, and defeated the sons of Attila and their remaining allies at the Battle of Nedao in 454. The Gepids and their allies subsequently founded kingdoms on the Middle Danube, bordering on the Roman Empire. The Gepid Kingdom was one of the most important and long-lasting of these, centered on Sirmium, and sometimes referred to as Gepidia. It covered a large part of the former Roman province of Dacia, north of the Danube, and compared to other Middle Danubian kingdoms it remained relatively uninvolved with Rome.

Euphemia (Greek: Εὐφημία, died 523 or 524), born Lupicina, was an Empress of the Eastern Roman Empire by marriage to Justin I.

Empress Euphemia is credited with the ecclesiastical policies of Justin and she founded a Church of Saint Euphemia, where she was buried following her death, probably in either 523 or 524. Justin was buried by her side in 527.