Juan Ponce de León II (1524–1591) was a Spanish official and an interim governor of Puerto Rico. Ponce de León II was the first governor to be born in Puerto Rico. He was named after his grandfather, Juan Ponce de León, who became the first European explorer and governor of Puerto Rico in 1508.
Juan Ponce de León y Loayza (born San Juan, Puerto Rico) was the son of Juan Ponce de León II, the interim Spanish governor of Puerto Rico in 1579. His mother was Isabel de Loayza born in Villa Talavera de la Reina, Toledo, Spain, the daughter of Governor Iñigo López de Cervantes y Loayza. The city of Ponce, Puerto Rico, was named after Juan Ponce de León y Loayza.