Joints in the context of "Ankylosing spondylitis"

Hereditary haemochromatosis type 1 (HFE-related haemochromatosis) is a genetic disorder characterized by excessive intestinal absorption of dietary iron, resulting in a pathological increase in total body iron stores. Humans, like most animals, have no mechanism to regulate excess iron, simply losing a limited amount through various means like sweating or menstruating.

Excess iron accumulates in tissues and organs, disrupting their normal function. The most susceptible organs include the liver, heart, pancreas, skin, joints, gonads, thyroid and pituitary gland; patients can present with cirrhosis, polyarthropathy, hypogonadism, heart failure, or diabetes.

A leglock is a joint lock that is directed at joints of the leg such as the ankle, knee or hip joint. A leglock which is directed at joints in the foot is sometimes referred to as a foot lock and a lock at the hip as a hip lock. Leglocks are featured, with various levels of restrictions, in combat sports and martial arts such as Sambo, Brazilian Jiu-Jitsu, catch wrestling, mixed martial arts, Shootwrestling and submission wrestling, but are banned in some sports featuring joint locks such as judo. The technique has been seen across a wide range of different combat sports and is reportedly over 2,500 years old, having been seen in the lost art of Pankration in the original Olympic Games.

As with other jointlocks, leglocks are more effective with full body leverage. Some attack the large joints of the knee or hip and involve utilizing leverage to counteract the larger muscle groups, while others directly attack ligaments in the knee or the smaller joint of the ankle. Leglocks can involve control positions such as the inside leg triangle or leg knot to maintain control while applying the attack or transitioning between two attacks, though they and some other control positions are banned in Brazilian Jiu-jitsu competition. Some other leglock control positions have been adopted into modern BJJ and submission grappling competitions as "guards" such as the snake guard, one-legged X-guard, and 50/50 Guard, where they are used for both leglocks and to reverse into dominant positions from the bottom.