James, brother of Jesus in the context of "Ananus ben Ananus"

Paul, also named Saul of Tarsus, commonly known as Paul the Apostle or Saint Paul, was a Christian apostle (c. 5 – c. 64/65 AD) who spread the teachings of Jesus in the first-century AD. For his contributions towards the New Testament, he is generally regarded as one of the most important figures of the Apostolic Age, and he also founded several Christian communities in Asia Minor and Europe from the mid-40s to the mid-50s AD.

The main sources of information on Paul's life and works are Paul's letters and the Acts of the Apostles in the New Testament. Approximately half of its content documents his travels, preaching, and miracles. Paul was not one of the Twelve Apostles, and he did not know Jesus during his lifetime. Nonetheless, Paul was a contemporary of Jesus and personally knew eyewitnesses of Jesus such as his closest disciples (Peter and John) and brother James since the mid 30s AD, within a few years of the crucifixion (ca. 30–33 AD). He had knowledge of the life of Jesus and his teachings. According to the Acts, Paul lived as a Pharisee and participated in the persecution of early disciples of Jesus before his conversion. On his way to arrest Christians in Damascus, Paul saw a bright light, heard Christ speak, was blinded, and later healed by Ananias. After these events, Paul was baptized, beginning immediately to proclaim that Jesus of Nazareth was the Jewish messiah and the Son of God. He made three missionary journeys to spread the Christian message to non-Jewish communities.

The Syriac Orthodox Church (Classical Syriac: ܥܺܕܬܳܐ ܣܽܘܪܝܳܝܬܳܐ ܬܪܺܝܨܰܬ݂ ܫܽܘܒܚܳܐ, romanized: ʿIdto Sūryoyto Trīṣāth Šubḥō), also informally known as the Jacobite Church, is an Oriental Orthodox denomination that originated from the Church of Antioch. The Church currently has around 1.5 million followers worldwide. The Church upholds the Miaphysite doctrine in Christology and employs the Liturgy of Saint James, associated with James the Just. Classical Syriac is the official and liturgical language of the Church.

The supreme head of the Syriac Orthodox Church is the patriarch of Antioch, a bishop who, according to sacred tradition, continues the leadership passed down from Saint Peter. Since 2014, Ignatius Aphrem II has served as the Syriac Orthodox Antiochian patriarch. The Great Church of Antioch was the patriarchal seat and the headquarters of the Church until c. 518, after which Severus of Antioch had to flee to Alexandria, Egypt. After the death of Severus, the patriarchal seat moved from Egypt to different monasteries like the Mor Bar Sauma Monastery; some patriarchs also set up headquarters in Antioch temporarily. Later, Mor Hananyo Monastery was declared as the patriarchal seat and the headquarters of the Church from c. 1160 until 1932. In 1959, the patriarchal seat and headquarters were relocated to the Cathedral of Saint George in Bab Tuma, Damascus, Syria, due to conflicts in the region.

The Cathedral of Saint James (Armenian: Սրբոց Յակոբեանց Վանք Հայոց, Arabic: كاتدرائية القديس يعقوب للأرمن) is a 12th-century Armenian church in the Armenian Quarter of Jerusalem, near the quarter's entry Zion Gate. The cathedral is dedicated to two of the Twelve Apostles of Jesus: James, son of Zebedee (James the Greater) and James the brother of Jesus (James the Just). It is located near the Church of the Holy Archangels.

It is the principal church of the Armenian Patriarchate of Jerusalem, also known as the Armenian Patriarchate of Saint James.

The brothers of Jesus or the adelphoi (Ancient Greek: ἀδελφοί, romanized: adelphoí, lit. 'of the same womb, brothers') are named in the New Testament as James, Joses (a form of Joseph), Simon, and Jude; unnamed sisters are mentioned in Mark and Matthew. They may have been: (1) sons of Mary, the mother of Jesus, and Joseph; (2) sons of Joseph by a former marriage; or (3) sons of Mary of Clopas, named in Mark 15:40 as the "mother of James and Joses", who has been identified as either the sister of Mary, the mother of Jesus, or a sister-in-law to Joseph.

Those who uphold the perpetual virginity of Mary reject the idea of biological brethren and maintain that the brothers and sisters were either cousins of Jesus (option 3, the position of the Catholic Church) or children of Joseph from a previous marriage (option 2, the Eastern Orthodox Church). Some Lutheran Churches have accepted both option 2 and option 3 as being valid explanations for the doctrine of the perpetual virginity of Mary.