The Italian Wars were a series of conflicts fought between 1494 and 1559, mostly in the Italian Peninsula, later expanding into Flanders, the Rhineland and Mediterranean Sea. The primary belligerents were the Valois kings of France, on one side, and their Habsburg opponents in the Holy Roman Empire and Spain on the other. Numerous Italian states participated at different stages, some on both sides, with limited involvement from England, and the Ottoman Empire.
The 1454 Italic League achieved a balance of power in Italy, but disintegrated after the death of its chief architect, Lorenzo de' Medici, in 1492. Combined with the ambition of Ludovico Sforza, its collapse allowed Charles VIII of France to invade Naples in 1494, which drew in Spain and the Holy Roman Empire. Although Charles was forced to withdraw in 1495, ongoing political divisions among the Italian states made them a battleground in the struggle for European domination between France and the Habsburgs.
