The Inuvialuit Settlement Region (ISR; Inuinnaqtun: Inuvialuit Nunangit Sannaiqtuaq – INS; French: Région désignée des Inuvialuit – RDI), located in Canada's western Arctic, was designated in 1984 in the Inuvialuit Final Agreement by the Government of Canada for the Inuvialuit. It spans 435,000 km (270,000 mi), including 90,650 km (35,000 sq mi) of land and 12,980 km (5,010 sq mi) of subsurface mineral rights. The ISR is mainly above the tree line, and includes several sub-regions: the Beaufort Sea, the Mackenzie River delta, the northern portion of Yukon ("Yukon North Slope", Herschel Island), and the northwest portion of the Northwest Territories. The ISR includes both Crown Lands and Inuvialuit Private Lands. Most of the ISR is represented by Nunakput, the territorial electoral district, meaning "our land" in Inuvialuktun.
The ISR is one of the four Inuit regions of Canada, collectively known as Inuit Nunangat, represented by the Inuit Tapiriit Kanatami (ITK). The other regions include Nunatsiavut in Labrador, Nunavik in northern Quebec, and the territory of Nunavut. The ISR is the homeland of the Inuvialuit. The Inuvialuit Regional Corporation, established in 1986 as the receiver of the lands and financial compensation of the Inuvialuit Final Agreement, is controlled by the Inuvialuit population and is responsible for ISR operations. From 1996 until 2016, Nellie Cournoyea, former Premier of the Northwest Territories, was the Chair and CEO of the Board. She had been elected nine times before declining to run again. In 2016, Duane Ningaqsiq Smith, was elected to replace her, was re-elected in 2019, and acclaimed in 2022.