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Charles Street, known for most of its route as Maryland Route 139 (MD 139), runs through Baltimore and the Towson area of Baltimore County. On the north end, it terminates at an intersection with Bellona Avenue near Interstate 695 (I-695). At the south end, it terminates in Federal Hill in Baltimore. Charles Street is one of the major routes through Baltimore, and is a major public transportation corridor. For the one-way portions of Charles Street, the street is functionally complemented by the parallel St. Paul Street, including St. Paul Place and Preston Gardens, Maryland Avenue, Cathedral Street, and Liberty Street.
Though not exactly at the west–east midpoint of the city, Charles Street is the dividing line between the west and east sides of Baltimore. On any street that crosses Charles Street, address numbers start from the unit block on either side, and the streets are identified as either "West" or "East," depending on whether they are to the west or east of Charles.