Inhibitory control in the context of "Methylphenidate"

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⭐ Core Definition: Inhibitory control

Inhibitory control, also known as response inhibition, is a cognitive process – and, more specifically, an executive function – that permits an individual to inhibit their impulses and natural, habitual, or dominant behavioral responses to stimuli (a.k.a. prepotent responses) in order to select a more appropriate behavior that is consistent with completing their goals. Self-control is an important aspect of inhibitory control. For example, successfully suppressing the natural behavioral response to eat cake when one is craving it while dieting requires the use of inhibitory control.

The prefrontal cortex, caudate nucleus, and subthalamic nucleus are known to regulate inhibitory control cognition. Inhibitory control is impaired in both addiction and attention deficit hyperactivity disorder. In healthy adults and ADHD individuals, inhibitory control improves over the short term with low (therapeutic) doses of methylphenidate or amphetamine. Inhibitory control may also be improved over the long-term via consistent aerobic exercise.

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👉 Inhibitory control in the context of Methylphenidate

Methylphenidate, sold under the brand name Ritalin and Concerta, among others, is a central nervous system (CNS) stimulant used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It may be taken by mouth or applied to the skin, and different formulations have varying durations of effect. For ADHD, the effectiveness of methylphenidate is comparable to atomoxetine but modestly lower than amphetamine. Methylphenidate reduces core ADHD symptoms and may do so in part by enhancing cognitive control of behavior (i.e., working memory and inhibitory control).

At therapeutic doses, methylphenidate increases alertness and concentration and reduces hyperactivity and impulsive behavior in individuals with ADHD. Common side effects include loss of appetite, weight loss, trouble sleeping, and small increases in heart rate and blood pressure. Long-term treatment in children has been associated with slightly slower growth. Methylphenidate can be misused; dependence and withdrawal are mainly reported with high-dose or non-medical use and are uncommon at therapeutic doses.

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Inhibitory control in the context of Self-control

Self-control is an aspect of inhibitory control, one of the core executive functions. Executive functions are cognitive processes that are necessary for regulating one's behavior in order to achieve specific goals.

Defined more independently, self-control is the ability to regulate one's emotions, thoughts, and behavior in the face of temptations and impulses. Thought to be like a muscle, acts of self-control expend a limited resource. In the short term, use of self-control can lead to the depletion of that resource. However, in the long term, the use of self-control can strengthen and improve the ability to control oneself over time.

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Inhibitory control in the context of Executive functions

In cognitive science and neuropsychology, executive functions (collectively referred to as executive function and cognitive control) are a set of cognitive processes that support goal-directed behavior, by regulating thoughts and actions through cognitive control, selecting and successfully monitoring actions that facilitate the attainment of chosen objectives. Executive functions include basic cognitive processes such as attentional control, cognitive inhibition, inhibitory control, working memory, and cognitive flexibility. Higher-order executive functions require the simultaneous use of multiple basic executive functions and include planning and fluid intelligence (e.g., reasoning and problem-solving).

Executive functions gradually develop and change across the lifespan of an individual and can be improved at any time over the course of a person's life. Similarly, these cognitive processes can be adversely affected by a variety of events which affect an individual. Both neuropsychological tests (e.g., the Stroop test) and rating scales (e.g., the Behavior Rating Inventory of Executive Function) are used to measure executive functions. They are usually performed as part of a more comprehensive assessment to diagnose neurological and psychiatric disorders.

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Inhibitory control in the context of Control (psychology)

In psychology, control is a person's ability or perception of their ability to affect themselves, others, their conditions, their environment or some other circumstance. Control over oneself or others can extend to the regulation of emotions, thoughts, actions, impulses, memory, attention or experiences. There are several types of control, including:

  • Perceived control (a person's perception of their own control and abilities to achieve outcomes)
  • Desired control (the amount of control one seeks within a relationship or other circumstance)
  • Cognitive control (the ability to select one's thoughts and actions)
  • Emotional control (the ability to regulate one's feelings or attitudes toward something)
  • Motivational control (one's ability to act on prescribed behaviors)
  • Inhibitory control (the ability to inhibit thoughts or actions in favor of others)
  • Social control (selecting one's environment for personal benefit)
  • Ego control (the attempt to regulate impulses or attention processes)
  • Effortful control (the ability to regulate how much effort one invests into a goal)
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Inhibitory control in the context of Caudate nucleus

The caudate nucleus is one of the structures that make up the corpus striatum, which is part of the basal ganglia in the human brain. Although the caudate nucleus has long been associated with motor processes because of its relation to Parkinson's disease and Huntington's disease, it also plays important roles in nonmotor functions, such as procedural learning, associative learning, and inhibitory control of action. The caudate is also one of the brain structures that compose the reward system, and it functions as part of the cortico-basal ganglia-thalamo-cortical loop.

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Inhibitory control in the context of Intercalated cells of the amygdala

The Intercalated cells of the amygdala (ITC or ICCs) are GABAergic neurons situated between the basolateral and central nuclei of the amygdala that play a significant role in inhibitory control over the amygdala. They regulate amygdala-dependent emotional processing like fear memory and social behavior. Their function has been best studied with selective ITC ablation which impairs fear extinction, fear generalization, and social behavior. Studies have begun to recognize that ITC clusters may be implicated in reward, addiction, and withdrawal circuits given their heavy expression of dopamine and opioid receptors.

In rodents, ITCs are organized into distinct clusters that wrap the basolateral amygdala (BLA). Each cluster is unique in connectivity, intrinsic properties, and function. These clusters are named by their location relative to the BLA with medial ITC clusters towards the central amygdala.

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Inhibitory control in the context of Self control

Self-control is the ability to regulate one's emotions, thoughts, and behavior in the face of temptations and impulses. It is an aspect of inhibitory control, one of the core human executive functions. Executive functions are cognitive processes that are necessary for regulating one's behavior in order to achieve specific goals.

As an executive function, self-control supports goal-directed behavior, planning, and decision making. In psychology, self-control is often distinguished from the broader construct of self-regulation, which includes the monitoring, adjustment, and maintenance of behavior and emotional states across changing situations.

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