Illegal drug in the context of "Drug test"

Legalization is the process of removing a legal prohibition against something which is currently not legal.

Legalization is a process often applied to what are regarded, by those working towards legalization, as victimless crimes, of which one example is the consumption of illegal drugs (see drug legalization).

A detection dog or sniffer dog is a dog that is trained to use its senses to detect substances such as explosives, illegal drugs, wildlife scat, semen, currency, blood, and contraband electronics, such as illicit mobile phones. The sense most used by detection dogs is smell. Hunting dogs that search for game, and search and rescue dogs that work to find missing humans are generally not considered detection dogs but fit instead under their own categories. There is some overlap, as in the case of cadaver dogs, trained to search for human remains.

A police dog is essentially a detection dog that is used as a resource, for police in specific scenarios such as conducting drug raids, finding missing criminals, and locating stashed currency. Frequently, detection dogs are thought to be used for law enforcement purposes. Experts say that dog-sniff evidence should not be used in the criminal justice system, pointing to wrongful convictions, human biases that skew animal behavior, and the lack of systematic research into what dogs detect or how they do it.

A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI or TUI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine. Monoamine structures (including neurotransmitters) contain a singular amino group (mono) linked to an aromatic ring by a chain of two carbons. SNDRIs prevent reuptake of these monoamine neurotransmitters through the simultaneous inhibition of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), respectively, increasing their extracellular concentrations and, therefore, resulting in an increase in serotonergic, adrenergic, and dopaminergic neurotransmission. SNDRIs were developed as potential antidepressants and treatments for other disorders, such as obesity, cocaine addiction, attention-deficit hyperactivity disorder (ADHD), and chronic pain. The increase in neurotransmitters through triple reuptake inhibition (including the addition of dopaminergic action) has the potential to heighten therapeutic effects in comparison to selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), reducing symptoms of depression and anxiety in people struggling with mental illness, as well as potentially combating other ailments such as those listed above.

However, increased side effects and abuse potential are concerns when using these agents relative to their SSRI and SNRI counterparts. Additionally, SNDRIs include the naturally occurring drug cocaine, a widely used recreational and often illegal drug for the euphoric effects it produces. Ketamine and phencyclidine are also SNDRIs and are similarly encountered as drugs of abuse. To a lesser extent, MDMA also acts as a SNDRI.