Ponce (US: /ˈpɔːnseɪ, ˈpoʊn-/ PAWN-say, POHN-, UK: /ˈpɒn-/ PON-, Spanish: [ˈponse] ) is a city and a municipality on the southern coast of Puerto Rico. The most populated city outside the San Juan metropolitan area, Ponce was founded on August 12, 1692 and is named after Juan Ponce de León y Loayza, the great-grandson of Spanish conquistador Juan Ponce de León. Ponce is often referred to as La Perla del Sur (The Pearl of the South), La Ciudad Señorial (The Manorial City), and La Ciudad de las Quenepas (Genip City).
The city serves as the governmental seat of the autonomous municipality as well as the regional hub for various government of Puerto Rico entities, such as the Supreme Court of Puerto Rico. It is also the regional center for various U.S. federal government agencies. Ponce is a principal city of both the Ponce Metropolitan Statistical Area and the Ponce-Yauco-Coamo Combined Statistical Area with, as of the 2020 US Census, a population of 278,477 and 333,426 respectively.