The Huon River (/ˈhjuːɒnˈrɪvə/ HYOO-on-RIV-ə, Mellukerdee/palawa kani: Taloonne) is a perennial river in the southwest and southeast regions of Tasmania, Australia. At 174 kilometres (108 mi) long, the Huon River is the fifth-longest in the state, with its course flowing east through the fertile Huon Valley and emptying into the D'Entrecasteaux Channel, before flowing into the Tasman Sea.
At its mouth, the Huon River is over 5 kilometres (3 mi) wide, and in the lower reaches, the river's average depth is 3 metres (10 ft), with maximum depths of up to 12 metres (39 ft). The Egg Islands, in this lower tidal zone, are ecologically significant for their rich wetlands and birdlife.