Human variability in the context of "Disease"

⭐ In the context of Disease, Human variability is considered…

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⭐ Core Definition: Human variability

Human variability, or human variation, is the range of possible values for any characteristic, physical or mental, of human beings.

Frequently debated areas of variability include cognitive ability, personality, physical appearance (body shape, skin color, etc.) and immunology.Variability is partly heritable and partly acquired (nature vs. nurture debate).As the human species exhibits sexual dimorphism, many traits show significant variation not just between populations but also between the sexes.

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👉 Human variability in the context of Disease

A disease is a particular abnormal condition that adversely affects the structure or function of all or part of an organism and is not immediately due to any external injury. Diseases are often known to be medical conditions that are associated with specific signs and symptoms. A disease may be caused by external factors such as pathogens or by internal dysfunctions. For example, internal dysfunctions of the immune system can produce a variety of different diseases, including various forms of immunodeficiency, hypersensitivity, allergies, and autoimmune disorders.

In humans, disease is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person affected, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories. Diseases can affect people not only physically but also mentally, as contracting and living with a disease can alter the affected person's perspective on life.

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Human variability in the context of Early modern human

Early modern human, or anatomically modern human, are terms used to distinguish Homo sapiens (the only extant Hominina species) that are anatomically consistent with the range of phenotypes seen in contemporary humans, from extinct archaic human species. This distinction is useful especially for times and regions where anatomically modern and archaic humans co-existed, for example, in Paleolithic Europe. Among the oldest known remains of Homo sapiens are those found at the Omo-Kibish I archaeological site in south-western Ethiopia, dating to about 233,000 to 196,000 years ago, the Florisbad Skull found at the Florisbad archaeological and paleontological site in South Africa, dating to about 259,000 years ago, and the Jebel Irhoud site in Morocco, dated about 315,000 years ago.

Extinct species of the genus Homo include Homo erectus (extant from roughly 2,000,000 to 100,000 years ago) and a number of other species (by some authors considered subspecies of either H. sapiens or H. erectus). The divergence of the lineage leading to H. sapiens out of ancestral H. erectus (or an intermediate species such as Homo antecessor) is estimated to have occurred in Africa roughly 500,000 years ago. The earliest fossil evidence of early modern humans appears in Africa around 300,000 years ago, with the earliest genetic splits among modern people, according to some evidence, dating to around the same time. Sustained archaic human admixture with modern humans is known to have taken place both in Africa and (following the recent Out-Of-Africa expansion) in Eurasia, between about 100,000 and 30,000 years ago.

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