Howard Hughes Medical Institute in the context of "Carolyn R. Bertozzi"

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⭐ Core Definition: Howard Hughes Medical Institute

The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland, with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, film director, and philanthropist, known during his lifetime as one of the most financially successful individuals in the world. It is one of the largest private funding organizations for biological and medical research in the United States. HHMI spends about $1 million per HHMI Investigator per year, which amounts to annual investment in biomedical research of about $825 million.

The institute has an endowment of $22.6 billion, making it the second-wealthiest philanthropic organization in the United States and the second-best-endowed medical research foundation in the world. HHMI is the former owner of the Hughes Aircraft Company, an American aerospace firm that was divested to various firms over time.

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👉 Howard Hughes Medical Institute in the context of Carolyn R. Bertozzi

Carolyn Ruth Bertozzi (born October 10, 1966) is an American chemist and Nobel laureate, known for her wide-ranging work spanning both chemistry and biology. She coined the term "bioorthogonal chemistry" for chemical reactions compatible with living systems. Her recent efforts include synthesis of chemical tools to study cell surface sugars called glycans and how they affect diseases such as cancer, inflammation, and viral infections like COVID-19. At Stanford University, she holds the Anne T. and Robert M. Bass Professorship in the School of Humanities and Sciences. Bertozzi is also an Investigator at the Howard Hughes Medical Institute (HHMI) and is the former director of the Molecular Foundry, a nanoscience research center at Lawrence Berkeley National Laboratory. Since 2024, she has served as a scientific advisory board member of Arc Institute.

She received the MacArthur "genius" award at age 33. In 2010, she was the first woman to receive the prestigious Lemelson–MIT Prize faculty award. She is a member of the National Academy of Sciences (2005), the Institute of Medicine (2011), and the National Academy of Inventors (2013). In 2014, it was announced that Bertozzi would lead ACS Central Science, the American Chemical Society's first peer-reviewed open access journal, which offers all content free to the public. Since 2021 she has been a member of the Accademia dei Lincei.

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Howard Hughes Medical Institute in the context of Eric Kandel

Eric Richard Kandel (German: [ˈkandəl]; born Erich Richard Kandel, November 7, 1929) is an Austrian-born American medical doctor who specialized in psychiatry. He was also a neuroscientist and a professor of biochemistry and biophysics at the College of Physicians and Surgeons at Columbia University. He was a recipient of the 2000 Nobel Prize in Physiology or Medicine for his research on the physiological basis of memory storage in neurons. He shared the prize with Arvid Carlsson and Paul Greengard.

Kandel was from 1984 to 2022 a Senior Investigator in the Howard Hughes Medical Institute. He was in 1975 the founding director of the Center for Neurobiology and Behavior, which is now the Department of Neuroscience at Columbia University. He currently serves on the Scientific Council of the Brain & Behavior Research Foundation. Kandel's popularized account chronicling his life and research, In Search of Memory: The Emergence of a New Science of Mind, was awarded the 2006 Los Angeles Times Book Prize for Science and Technology.

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Howard Hughes Medical Institute in the context of Salk Institute

The Salk Institute for Biological Studies is a scientific research institute in the La Jolla community of San Diego, California. The independent, non-profit institute was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Construction of the research facilities began in spring of 1962. The Salk Institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences.

As of October 2020, the Salk Institute employs 850 researchers in 60 research groups and focuses its research in three areas: molecular biology and genetics; neurosciences; and plant biology. Research topics include aging, cancer, diabetes, birth defects, Alzheimer's disease, Parkinson's disease, AIDS, and the neurobiology of American Sign Language. March of Dimes provided the initial funding and continues to support the institute. Research is funded by a variety of public sources, such as the US National Institutes of Health and the government of California; and private organizations such as Paris-based Ipsen, the Howard Hughes Medical Institute and the Waitt Family Foundation. In addition, the internally administered Innovation Grants Program encourages cutting-edge high-risk research. In 2017 the Salk Institute Trustees elected former president of Booz Allen Hamilton, Daniel C. Lewis, as board chairman.

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Howard Hughes Medical Institute in the context of David Baker (biochemist)

David Baker (born October 6, 1962) is an American biochemist and computational biologist who has pioneered methods to design proteins and predict their three-dimensional structures. He is the Henrietta and Aubrey Davis Endowed Professor in Biochemistry, an investigator with the Howard Hughes Medical Institute, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington. He was awarded the shared 2024 Nobel Prize in Chemistry for his work on computational protein design.

Baker is a member of the United States National Academy of Sciences and the director of the University of Washington's Institute for Protein Design. He has co-founded more than a dozen biotechnology companies and was included in Time magazine's inaugural list of the 100 Most Influential People in health in 2024.

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Howard Hughes Medical Institute in the context of Jennifer Doudna

Jennifer Anne Doudna ForMemRS (/ˈddnə/; born February 19, 1964) is an American biochemist who has pioneered work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing." She is the Li Ka Shing Chancellor's Chair Professor in the department of chemistry and the department of molecular and cell biology at the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute since 1997.

In 2012, Doudna and Emmanuelle Charpentier were the first to propose that CRISPR-Cas9 (enzymes from bacteria that control microbial immunity) could be used for programmable editing of genomes, which has been called one of the most significant discoveries in the history of biology. Since then, Doudna has been a leading figure in what is referred to as the "CRISPR revolution" for her fundamental work and leadership in developing CRISPR-mediated genome editing.

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Howard Hughes Medical Institute in the context of Thomas A. Steitz

Thomas Arthur Steitz (August 23, 1940 – October 9, 2018) was an American biochemist, a Sterling Professor of Molecular Biophysics and Biochemistry at Yale University, and investigator at the Howard Hughes Medical Institute, best known for his pioneering work on the ribosome.

Steitz was awarded the 2009 Nobel Prize in Chemistry along with Venkatraman Ramakrishnan and Ada Yonath "for studies of the structure and function of the ribosome". Steitz also won the Gairdner International Award in 2007 "for his studies on the structure and function of the ribosome which showed that the peptidyl transferase (EC 2.3.2.12) was an RNA catalyzed reaction, and for revealing the mechanism of inhibition of this function by antibiotics".

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