House of Mihran in the context of "Chosroid dynasty"

The Seven Great Houses of Iran, also known as the seven Parthian clans, were seven aristocracies of Parthian origin, who were allied with the Sasanian court. The Parthian clans all claimed ancestry from Achaemenid Persians.

The seven Great Houses of Iran had played an active role in Iranian politics since the days of the Arsacid Empire, which they continued to do under their successors, the Sasanians. Only two of the seven – the House of Suren and the House of Karen – however, are actually attested in sources date-able to the Parthian period. The seven houses claimed to have been confirmed as lords in Iran by the legendary Kayanian king Vishtaspa. "It may be that [...] members of them made up their own genealogies in order to emphasize the antiquity of their families." During Sasanian times, the seven feudal houses played a significant role at the Sasanian court. Bahram Chobin, a famed military commander of Hormizd IV (r. 579–590), was from the House of Mihran.

The Sasanian civil war of 589–591 was a conflict that broke out in 589, due to the great deal of dissatisfaction among the nobles towards the rule of Hormizd IV. The civil war lasted until 591, ending with the overthrow of the Mihranid usurper Bahram Chobin and the restoration of the Sasanian family as the rulers of Iran.

The reason for the civil war was due to king Hormizd IV's hard treatment towards the nobility and clergy, whom he distrusted. This eventually made Bahram Chobin start a major rebellion, while the two Ispahbudhan brothers Vistahm and Vinduyih made a palace coup against him, resulting in the blinding and eventually death of Hormizd IV. His son, Khosrow II, was thereafter crowned as king.

Bahrām Chōbīn (Persian: بهرام چوبین) or Wahrām Chōbēn (Middle Persian: 𐭥𐭫𐭧𐭫𐭠𐭭; died 591), also known by his epithet Mehrbandak ("servant of Mithra"), was a nobleman, general, and political leader of the late Sasanian Empire and briefly its ruler as Bahram VI (r. 590–591).

Son of general Bahram Gushnasp and hailing from the noble House of Mihran, Bahram began his career as the governor of Ray, and was promoted to the army chief (spahbed) of the northwestern portions of the empire after capturing the Byzantine stronghold of Dara, fighting in the war of 572–591. After a massive Hephthalite-Turkic invasion of the eastern Sasanian domains in 588, he was appointed as the spahbed in Khorasan, beginning a campaign that ended in a decisive Iranian victory.

Vistahm or Bistam (also transliterated Wistaxm, Middle Persian: 𐭥𐭮𐭲𐭧𐭬 wsthm), was a Parthian dynast of the Ispahbudhan house, and maternal uncle of the Sasanian king of kings of Iran, Khosrow II (r. 590–628). Vistahm helped Khosrow regain his throne after the rebellion of another Parthian noble Bahram Chobin, of House of Mihran, but later led a revolt himself, and ruled independently over a region which encompassed the entire Iranian East until he was defeated by Khosrow and his allies.

Hormizd III (Middle Persian: 𐭠𐭥𐭧𐭥𐭬𐭦𐭣; New Persian: هرمز سوم), was the seventeenth king (shah) of the Sasanian Empire, ruling briefly from 457 to 459. He was the son and successor of Yazdegerd II (r. 438–457). His reign was marked by the rebellion of his younger brother Peroz I, who with the aid of one of the Seven Great Houses of Iran, the House of Mihran, and the eastern neighbours of the Sasanians, the Hephthalites, had him captured and executed.

Izadgushasp (also spelled Yazdgushnasp), known in Byzantine sources as Isdigousnas Zikh, was an Iranian nobleman from the House of Mihran, who served as one of Khosrow I's viziers (wuzurg framadar).