Hodgkin lymphoma in the context of "Lymphoma"

The Epstein–Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus. EBV is the first identified oncogenic virus, a virus that can cause cancer. EBV establishes a permanent infection in human B cells. It uncommonly causes infectious mononucleosis and is also tightly linked to many malignant diseases (cancers and autoimmune diseases). Various vaccine formulations have been tested in humans and other animals; however, none of them were able to prevent EBV infection, thus, no vaccine has been approved to date.

Infectious mononucleosis ("mono" or "glandular fever"), is characterized by extreme fatigue, fever, sore throat, and swollen lymph nodes. EBV is also associated with various non-malignant, premalignant, and malignant EBV-associated lymphoproliferative diseases such as Burkitt lymphoma, hemophagocytic lymphohistiocytosis, and Hodgkin's lymphoma; non-lymphoid malignancies such as gastric cancer and nasopharyngeal carcinoma; and conditions associated with human immunodeficiency virus such as hairy leukoplakia and central nervous system lymphomas. The virus is also associated with the childhood disorders of Alice in Wonderland syndrome and acute cerebellar ataxia and, by some evidence, higher risks of developing certain autoimmune diseases, especially dermatomyositis, systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome. About 200,000 cancer cases globally per year are thought to be attributable to EBV. In 2022, a large study following 10 million active US military over 20 years suggested EBV as the leading cause of multiple sclerosis (MS), with a recent EBV infection causing a 32-fold increase in MS risk development.

Paul Gardner Allen (January 21, 1953 – October 15, 2018) was an American businessman, computer programmer and investor. He co-founded Microsoft Corporation with his childhood friend Bill Gates in 1975, which was followed by the microcomputer revolution of the 1970s and 1980s. He was also known for discovering the wrecks of various famous warships, like the IJN Musashi and USS Indianapolis. Allen was ranked as one of the richest people in American history by Forbes with an estimated net worth of $20.3 billion at the time of his death in October 2018.

Allen quit from day-to-day work at Microsoft in early 1983 after a Hodgkin lymphoma diagnosis, remaining on its board as vice-chairman. He and his sister, Jody Allen, founded Vulcan Inc. in 1986, a privately held company that managed his business and philanthropic efforts. At the time of his death, he had a multi-billion dollar investment portfolio, including technology and media companies, scientific research, real estate holdings, private space flight ventures and stakes in other sectors. He owned the Seattle Seahawks of the National Football League and the Portland Trail Blazers of the National Basketball Association, and was part-owner of the Seattle Sounders FC of Major League Soccer. Under Allen's helm, the Seahawks won Super Bowl XLVIII and made it to two other Super Bowls (XL and XLIX). In 2000 he resigned from his position on Microsoft's board and assumed the post of senior strategy advisor to the company's management team.